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General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-1615
Gene Name: synuclein, beta
Gene Symbol: sncb    Nomenclature History

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Previous Names: zgc:66343, zSyn-β (1), zSynC (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Involved in dopaminergic neuron differentiation and larval locomotory behavior. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Is expressed in basal plate midbrain region; nervous system; pleuroperitoneal region; and trigeminal placode. Orthologous to several human genes including SNCB (synuclein beta).
Genome Resources: Alliance (1),  Gene:393944 (1),  Ensembl(GRCz11):ENSDARG00000104945 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-sncb N/A 1
MO2-sncb N/A 1
PHENOTYPE
Data: Fig. 6 from Milanese et al., 2012
Observed in:
DISEASE ASSOCIATED WITH sncb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Lewy body dementia Alliance Dementia, Lewy body 127750
DISEASE ASSOCIATED WITH sncb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process dopaminergic neuron differentiation (more)
Cellular Component cytoplasm (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001058 (1)
  • InterPro:IPR002461 (1)
  • Pfam:PF01387 (1)
  • TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-sncb monoclonal IgG1 Mouse IHC, WB Cell Signaling Technology, Inc.
    3
    CONSTRUCTS WITH SEQUENCES FROM sncb No data available
    MARKER RELATIONSHIPS
    sncb Encodes: [EST] IMAGE:6903488 (1) (order this)
    [cDNA] MGC:66343 (1) (order this), MGC:195060 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200969 (1)
    Polypeptide UniProtKB:Q7SX92 (1) 127 aa
    Sequence Clusters UniGene:80813 (1)
    Sequence Information (all 16)
    ORTHOLOGY for sncb ( Chr: 14 )
    CITATIONS (31)