Gene
sncb
- ID
- ZDB-GENE-040426-1615
- Name
- synuclein, beta
- Symbol
- sncb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Involved in dopaminergic neuron differentiation and larval locomotory behavior. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Is expressed in basal plate midbrain region; nervous system; pleuroperitoneal region; and trigeminal placode. Orthologous to several human genes including SNCB (synuclein beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66343 (9 images)
- IMAGE:6903488 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Milanese et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lewy body dementia | Alliance | Dementia, Lewy body | 127750 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Beta-synuclein | Synuclein |
|---|---|---|---|
|
UniProtKB:Q7SX92
|
127 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-sncb | monoclonal | IgG1 | Mouse |
|
Cell Signaling Technology, Inc.
|
3 |
Plasmids