Gene

cdc73

ID
ZDB-GENE-040426-1309
Name
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Symbol
cdc73 Nomenclature History
Previous Names
  • hrpt2 (1)
  • sun (1)
  • sunrise (1)
  • zgc:63956
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have RNA polymerase II complex binding activity. Involved in erythrocyte differentiation; regulation of transcription elongation from RNA polymerase II promoter; and spinal cord oligodendrocyte cell differentiation. Localizes to Cdc73/Paf1 complex. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdc73 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hyperparathyroidism Alliance Hyperparathyroidism, familial primary 145000
hyperparathyroidism Alliance Hyperparathyroidism-jaw tumor syndrome 145001
hyperparathyroidism Alliance Parathyroid adenoma with cystic changes 145001
parathyroid carcinoma Alliance Parathyroid carcinoma 608266
Associated With cdc73 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR031336 Cell division control protein 73, C-terminal
Domain IPR032041 Paf1 complex subunit Cdc73, N-terminal domain
Family IPR007852 Cdc73/Parafibromin
Homologous_superfamily IPR038103 Cell division control protein 73, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Cdc73/Parafibromin Cell division control protein 73, C-terminal Cell division control protein 73, C-terminal domain superfamily Paf1 complex subunit Cdc73, N-terminal domain
UniProtKB:Q7T3D4 521
UniProtKB:X1WHN7 530
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cdc73-201 (1) Ensembl 1,791 nt
mRNA cdc73-202 (1) Ensembl 2,515 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cdc73 polyclonal IgG Rabbit
  • WB
Sigma-Aldrich
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations