ZFIN ID: ZDB-GENE-040426-1309
Gene Name: cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Gene Symbol: cdc73    Nomenclature History

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Previous Names: hrpt2 (1), sun (1), sunrise (1), zgc:63956

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II complex binding activity. Involved in erythrocyte differentiation; regulation of transcription elongation from RNA polymerase II promoter; and spinal cord oligodendrocyte cell differentiation. Localizes to the Cdc73/Paf1 complex. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73).
Genome Resources: Alliance (1),  Gene:393319 (1),  Ensembl(GRCz11):ENSDARG00000020201 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63956]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cz400 Point Mutation Unknown Premature Stop ENU
sa15197 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17847 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cdc73 N/A 1
    MO2-cdc73 N/A 1
    MO3-cdc73 N/A 1
    DISEASE ASSOCIATED WITH cdc73 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hyperparathyroidism Alliance Hyperparathyroidism, familial primary 145000
    Hyperparathyroidism-jaw tumor syndrome 145001
    Parathyroid adenoma with cystic changes 145001
    parathyroid carcinoma Alliance Parathyroid carcinoma 608266
    DISEASE ASSOCIATED WITH cdc73 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process erythrocyte differentiation (more)
    Cellular Component Cdc73/Paf1 complex (more)
    Molecular Function RNA polymerase II complex binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR007852 Cdc73/Parafibromin
    Domain IPR031336 Cell division control protein 73, C-terminal
    Domain IPR032041 Paf1 complex subunit Cdc73, N-terminal domain
    Homologous_superfamily IPR038103 Cell division control protein 73, C-terminal domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdc73-201 (1)    Ensembl 1791
    cdc73-202 (1)    Ensembl 2515
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cdc73 polyclonal IgG Rabbit WB Sigma-Aldrich
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdc73 No data available
    MARKER RELATIONSHIPS
    cdc73 Contained in: [BAC] CH73-187E18 (1), DKEY-245G22 (1) (order this)
    cdc73 Encodes: [cDNA] MGC:63956 (1), MGC:192483 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200348 (1) 1828 bp
    Genomic GenBank:CT573433 (1) 129063 bp
    Select Tool
    Polypeptide UniProtKB:X1WHN7 (1) 530 aa
    Sequence Information (all 15)
    ORTHOLOGY for cdc73 ( Chr: 2 )
    CITATIONS (27)