Gene
prkcbb
- ID
- ZDB-GENE-040426-1178
- Name
- protein kinase C, beta b
- Symbol
- prkcbb Nomenclature History
- Previous Names
-
- prkcb1
- zgc:63591 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including histone binding activity; nuclear androgen receptor binding activity; and protein serine/threonine kinase activity. Acts upstream of or within blood coagulation and embryonic hemopoiesis. Predicted to be located in nucleus. Is expressed in brain; retinal neural layer; and somite border. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015188Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015189Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024154Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028908Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13860 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20072 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-prkcbb | N/A | Eckfeldt et al., 2005 |
| MO2-prkcbb | N/A | Williams et al., 2011 |
| MO3-prkcbb | N/A | Williams et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | C1-like domain superfamily | C2 domain | C2 domain superfamily | Classical protein kinase C beta, catalytic domain | Diacylglycerol/phorbol-ester binding | Protein kinase, ATP binding site | Protein kinase C, alpha/beta/gamma types | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinases, AGC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QMW2
|
670 | ||||||||||||||
|
UniProtKB:Q7SY24
|
670 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkcbb-201
(1)
|
Ensembl | 4,340 nt | ||
| mRNA |
prkcbb-202
(1)
|
Ensembl | 4,732 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-prkcb1 | monoclonal | IgG1 | Mouse |
|
Santa Cruz Biotechnology, Inc.
|
5 | |
| Ab2-prkcb1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-296E5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-112M13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-208P14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-15H19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63591 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200978 (1) | 4369 nt | ||
| Genomic | GenBank:BX255942 (1) | 203225 nt | ||
| Polypeptide | UniProtKB:A0A2R8QMW2 (1) | 670 aa |
- Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Diez Del Corral, R., Neuhauss, S.C.F., Martínez-Morales, J.R. (2023) Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. eLIFE. 12:
- Carril Pardo, C.A., Massoz, L., Dupont, M.A., Bergemann, D., Bourdouxhe, J., Lavergne, A., Tarifeño-Saldivia, E., Helker, C.S., Stainier, D.Y., Peers, B., Voz, M.M., Manfroid, I. (2022) A δ-cell subpopulation with pro-β cell identity contributes to efficient age-independent recovery in a zebrafish diabetes model. eLIFE. 11:
- Wei, G., Zhang, X., Cai, C., Sheng, J., Xu, M., Wang, C., Gu, Q., Guo, C., Chen, F., Liu, D., Qian, F. (2022) Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway. Frontiers in Cellular Neuroscience. 16:840143
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
- Yin, S.J., Luo, Y.Q., Zhao, C.P., Chen, H., Zhong, Z.F., Wang, S., Wang, Y.T., Yang, F.Q. (2020) Antithrombotic effect and action mechanism of Salvia miltiorrhiza and Panax notoginseng herbal pair on the zebrafish. Chinese Medicine. 15:35
- Ma, Y., Zang, L., Wang, D., Jiang, J., Wang, C., Wang, X., Fang, F., Wang, H. (2019) Effects of miR-181a-5p abnormal expression on zebrafish (Danio rerio) vascular development following triclosan exposure. Chemosphere. 223:523-535
- Wang, C., Huang, W., Lin, J., Fang, F., Wang, X., Wang, H. (2019) Triclosan-induced liver and brain injury in zebrafish (Danio rerio) via abnormal expression of miR-125 regulated by PKCα/Nrf2/p53 signaling pathways. Chemosphere. 241:125086
- Haug, M.F., Gesemann, M., Berger, M., Neuhauss, S.C.F. (2018) Phylogeny and distribution of protein kinase C variants in the zebrafish. The Journal of comparative neurology. 526(7):1097-1109
- Qian, L., Cui, F., Yang, Y., Liu, Y., Qi, S., Wang, C. (2018) Mechanisms of developmental toxicity in zebrafish embryos (Danio rerio) induced by boscalid. The Science of the total environment. 634:478-487
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