Gene

mad1l1

ID

ZDB-GENE-040426-1081

Name

mitotic arrest deficient 1 like 1

Symbol

mad1l1 Nomenclature History

Previous Names

zgc:56571 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and mitotic spindle assembly checkpoint signaling. Predicted to act upstream of or within cell division. Predicted to be located in nucleus. Predicted to be active in kinetochore; mitotic spindle; and nuclear envelope. Human ortholog(s) of this gene implicated in lymphoma; mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition; and prostate cancer. Orthologous to human MAD1L1 (mitotic arrest deficient 1 like 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56571 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mad1l1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition	Alliance	Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition	620189
prostate cancer	Alliance	Prostate cancer, somatic	176807
		Lymphoma, B-cell, somatic

Associated With mad1l1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR008672	Spindle assembly checkpoint component Mad1

Domain Details Per Protein

Protein	Additional Resources	Length	Spindle assembly checkpoint component Mad1
UniProtKB:D9IWE2	InterPro	717

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	mad1l1-202 (1) Ensembl	Ensembl		4,042 nt	Select Tool ZFIN BLAST
ncRNA	mad1l1-002 (1) Ensembl	Ensembl		508 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations