Gene

alpl

ID

ZDB-GENE-040420-1

Name

alkaline phosphatase, biomineralization associated

Symbol

alpl Nomenclature History

Previous Names

alp (1)
zgc:56672

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable alkaline phosphatase activity. Acts upstream of or within bone mineralization and response to mechanical stimulus. Predicted to be located in side of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural keel; brain; cardiovascular system; eye; and opercular flap. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

43 figures from 31 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56672 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alpl Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
adult hypophosphatasia	Alliance	Hypophosphatasia, adult	146300
adult hypophosphatasia	Alliance	Odontohypophosphatasia	146300
childhood hypophosphatasia	Alliance	Hypophosphatasia, childhood	241510
infantile hypophosphatasia	Alliance	Hypophosphatasia, infantile	241500

Associated With alpl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018299	Alkaline phosphatase, active site
Family	IPR001952	Alkaline phosphatase
Homologous_superfamily	IPR017850	Alkaline-phosphatase-like, core domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:F1Q5B5	InterPro	561
UniProtKB:A0A8M9PUR2	InterPro	554
UniProtKB:A0A8M2BGI2	InterPro	527
UniProtKB:A0AB32TZ69	InterPro	463

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	alpl-201 (1) Ensembl	Ensembl	640 nt	Select Tool ZFIN BLAST
mRNA	alpl-202 (1) Ensembl	Ensembl	1,871 nt	Select Tool ZFIN BLAST
mRNA	alpl-203 (1) Ensembl	Ensembl	812 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations