Gene
alpl
- ID
- ZDB-GENE-040420-1
- Name
- alkaline phosphatase, biomineralization associated
- Symbol
- alpl Nomenclature History
- Previous Names
-
- alp (1)
- zgc:56672
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable alkaline phosphatase activity. Acts upstream of or within bone mineralization and response to mechanical stimulus. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural keel; brain; cardiovascular system; eye; and opercular flap. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56672 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adult hypophosphatasia | Alliance | Hypophosphatasia, adult | 146300 |
| adult hypophosphatasia | Alliance | Odontohypophosphatasia | 146300 |
| childhood hypophosphatasia | Alliance | Hypophosphatasia, childhood | 241510 |
| infantile hypophosphatasia | Alliance | Hypophosphatasia, infantile | 241500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Alkaline phosphatase | Alkaline phosphatase, active site | Alkaline-phosphatase-like, core domain superfamily |
|---|---|---|---|---|
|
UniProtKB:F1Q5B5
|
561 | |||
|
UniProtKB:A0A8M9PUR2
|
554 | |||
|
UniProtKB:A0A8M2BGI2
|
527 |
Interactions and Pathways
No data available
Plasmids
No data available