ZFIN ID: ZDB-GENE-040318-1
Gene Name: fibroblast growth factor 2
Gene Symbol: fgf2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have fibroblast growth factor receptor binding activity and growth factor activity. Involved in Kupffer's vesicle development. Predicted to localize to the extracellular region. Human ortholog(s) of this gene implicated in several diseases, including corneal neovascularization; diabetic neuropathy; gastric ulcer; impotence; and prostate adenocarcinoma. Is expressed in brain; eye; and forerunner cell group. Orthologous to human FGF2 (fibroblast growth factor 2).
Genome Resources: Alliance (1),  Gene:404231 (1),  Ensembl(GRCz11):ENSDARG00000104348 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-fgf2 N/A 2
DISEASE ASSOCIATED WITH fgf2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH fgf2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process Kupffer's vesicle development (more)
Cellular Component extracellular region (more)
Molecular Function fibroblast growth factor receptor binding (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR002209 Fibroblast growth factor family
Family IPR028223 Fibroblast growth factor 2
Homologous_superfamily IPR008996 Cytokine IL1/FGF
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-fgf2 polyclonal Mouse WB 1
PLASMIDS
Addgene:zbFGF
CONSTRUCTS WITH SEQUENCES FROM fgf2 No data available
MARKER RELATIONSHIPS
fgf2 Encodes: [cDNA] MGC:194019 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_212823 (1)
Polypeptide UniProtKB:A0A0R4IHF9 (1) 154 aa
Sequence Information (all 13)
ORTHOLOGY for fgf2 ( Chr: 14 )
CITATIONS (39)