Gene
crim1
- ID
- ZDB-GENE-040312-2
- Name
- cysteine rich transmembrane BMP regulator 1 (chordin-like)
- Symbol
- crim1 Nomenclature History
- Previous Names
-
- wu:fc29f08
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within blood vessel development; notochord morphogenesis; and somitogenesis. Predicted to be located in extracellular region and membrane. Is expressed in several structures, including axis; intermediate cell mass of mesoderm; notochord; otic vesicle; and posterior segment eye. Used to study cataract and microphthalmia. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Brastrom et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la020131Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027863Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa23146 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23147 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa23148 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42982 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-crim1 | N/A | (2) |
| MO2-crim1 | N/A | Kinna et al., 2006 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cataract | WT + MO1-crim1 | standard conditions | Brastrom et al., 2019 |
| microphthalmia | WT + MO1-crim1 | standard conditions | Brastrom et al., 2019 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Antistasin-like domain | Cysteine-rich motor neuron 1 | Cysteine-rich motor neuron 1 protein, C-terminal | Growth factor receptor cysteine-rich domain superfamily | Hirudin/antistatin | Insulin-like growth factor-binding protein, IGFBP | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T3Q2 | InterPro | 1027 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-248E9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-153J7 | ZFIN Curated Data | |
| Contained in | BAC | RP71-1A16 | ZFIN Curated Data | |
| Encodes | EST | fc29f08 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193853 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212821 (1) | 3144 nt | ||
| Genomic | GenBank:BX571670 (2) | 213920 nt | ||
| Polypeptide | UniProtKB:Q7T3Q2 (1) | 1027 aa |
- Brastrom, L.K., Scott, C.A., Dawson, D.V., Slusarski, D.C. (2019) A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish. Biomedicines. 7(2)
- Reeves, W.M., Wu, Y., Harder, M.J., Veeman, M.T. (2017) Functional and evolutionary insights from the Ciona notochord transcriptome.. Development (Cambridge, England). 144:3375-3387
- Thomas-Jinu, S., Gordon, P.M., Fielding, T., Taylor, R., Smith, B.N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C.H., Bielen, H., Williams, K.L., McCann, E.P., Nicholson, G.A., Pan-Vazquez, A., Fox, A.H., Bond, C.S., Talbot, W.S., Blair, I.P., Shaw, C.E., Houart, C. (2017) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron. 94(2):322-336.e5
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Kinna, G., Kolle, G., Carter, A., Key, B., Lieschke, G.J., Perkins, A., and Little, M.H. (2006) Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development. Mechanisms of Development. 123(4):277-287
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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