Gene
gja10b
- ID
- ZDB-GENE-040310-6
- Name
- gap junction protein alpha 10 b
- Symbol
- gja10b Nomenclature History
- Previous Names
-
- cx52.6 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables gap junction hemi-channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within cell communication. Located in gap junction. Is expressed in brain; heart; and retina. Orthologous to human GJA10 (gap junction protein alpha 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu908 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gja10b | Liu et al., 2023 | |
| CRISPR2-gja10b | Liu et al., 2023 | |
| MO1-gja10b | N/A | Sun et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Connexin | Connexin, conserved site | Connexin, N-terminal | Connexin, N-terminal domain superfamily | Gap junction protein, cysteine-rich domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B7L5 | InterPro | 474 | |||||
| UniProtKB:Q8JHW1 | InterPro | 466 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cx52.6-201
(1)
|
Ensembl | 2,114 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-cx52.6 | polyclonal | Rabbit |
|
1 | |||
| Ab1-cx52.6 | polyclonal | Rabbit |
|
3 |
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(gja10b:EGFP) |
|
| 1 | Klaassen et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-117E10 | ZFIN Curated Data | |
| Encodes | EST | eu908 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212819 (1) | 1401 nt | ||
| Genomic | GenBank:BX510339 (1) | 70879 nt | ||
| Polypeptide | UniProtKB:A0A8M2B7L5 (1) | 474 aa |
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
- Liu, J., Li, W., Jin, X., Lin, F., Han, J., Zhang, Y. (2023) Optimal tagging strategies for illuminating expression profiles of genes with different abundance in zebrafish. Communications biology. 6:13001300
- Lukowicz-Bedford, R.M., Farnsworth, D.R., Miller, A.C. (2022) Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis. G3 (Bethesda). 12(5):
- Mikalsen, S.O., Tausen, M., Í Kongsstovu, S. (2020) Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies. BMC Genomics. 21:223
- Usui, Y., Aramaki, T., Kondo, S., Watanabe, M. (2019) The minimal gap-junction network among melanophores and xanthophores required for stripe-pattern formation in zebrafish. Development (Cambridge, England). 146(22):
- Greb, H., Klaassen, L.J., Schultz, K., Kamermans, M., Zoidl, G., Weiler, R., Janssen-Bienhold, U. (2018) An alternative splice variant of zebrafish cx52.6 is expressed in retinal horizontal cells. Neuroscience. 388:191-202
- Elliott, S.B., Harvey-Girard, E., Giassi, A.C., Maler, L. (2017) Hippocampal-like circuitry in the pallium of an electric fish: Possible substrates for recursive pattern separation and completion. The Journal of comparative neurology. 525(1):8-46
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Klaassen, L.J., de Graaff, W., Van Asselt, J.B., Klooster, J., Kamermans, M. (2016) Specific connectivity between photoreceptors and horizontal cells in the zebrafish retina. Journal of neurophysiology. 116(6):2799-2814
- Luo, Q., Wu, C., Sun, S., Lu, F., Xie, L., Zhao, H., Zhong, X., Zhou, Q. (2016) The spatial-temporal expression and functional divergence of bach homologs in zebrafish Danio rerio. Journal of Fish Biology. 88(4):1584-97
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