Gene

ca2

ID
ZDB-GENE-031219-5
Name
carbonic anhydrase II
Symbol
ca2 Nomenclature History
Previous Names
  • CA17a (1)
  • ca2a (1)
  • cb1082 (1)
  • wu:fb50f02
  • wu:fk91a02
  • zCA2-like a (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Enables carbonate dehydratase activity. Acts upstream of or within several processes, including carbon dioxide transport; hypotonic salinity response; and sodium ion import across plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gill; integument; nervous system; neural tube; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (carbonic anhydrase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
37 figures from 19 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ca2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive osteopetrosis 3 Alliance Osteopetrosis, autosomal recessive 3, with renal tubular acidosis 259730
Associated With ca2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018338 Carbonic anhydrase, alpha-class, conserved site
Domain IPR001148 Alpha carbonic anhydrase domain
Family IPR023561 Carbonic anhydrase, alpha-class
Homologous_superfamily IPR036398 Alpha carbonic anhydrase domain superfamily
Domain Details Per Protein
Protein Length Alpha carbonic anhydrase domain Alpha carbonic anhydrase domain superfamily Carbonic anhydrase, alpha-class Carbonic anhydrase, alpha-class, conserved site
UniProtKB:Q6PFU7 260
UniProtKB:A0A385NIA3 260
UniProtKB:F1R454 260
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-ca2 polyclonal Rabbit
1
Ab2-ca2 polyclonal Rabbit
  • IHC
2
Ab1-ca2 polyclonal Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations