Gene

mmp13a

ID
ZDB-GENE-031202-2
Name
matrix metallopeptidase 13a
Symbol
mmp13a Nomenclature History
Previous Names
  • mmp13
  • MMPLg
  • MMPLh (1)
  • cb1034 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Involved in macrophage chemotaxis. Predicted to localize to extracellular matrix. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); bone disease (multiple); and ovarian carcinoma. Is expressed in several structures, including cardiovascular system; extension; head; intermediate cell mass of mesoderm; and leukocyte. Orthologous to human MMP13 (matrix metallopeptidase 13).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
43 figures from 32 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mmp13a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondyloepimetaphyseal dysplasia, Missouri type Alliance Metaphyseal anadysplasia 1 602111
spondyloepimetaphyseal dysplasia, Missouri type Alliance ?Spondyloepimetaphyseal dysplasia, Missouri type 602111
Metaphyseal dysplasia, Spahr type 250400
Associated With mmp13a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR021158 Peptidase M10A, cysteine switch, zinc binding site
Conserved_site IPR018486 Hemopexin, conserved site
Domain IPR000585 Hemopexin-like domain
Domain IPR001818 Peptidase M10, metallopeptidase
Domain IPR002477 Peptidoglycan binding-like
Domain IPR006026 Peptidase, metallopeptidase
Domain IPR033739 Peptidase M10A, catalytic domain
Family IPR021190 Peptidase M10A
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036365 PGBD-like superfamily
Homologous_superfamily IPR036366 PGBD superfamily
Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
Repeat IPR018487 Hemopexin-like repeats
Domain Details Per Protein
Protein Length Hemopexin, conserved site Hemopexin-like domain Hemopexin-like domain superfamily Hemopexin-like repeats Metallopeptidase, catalytic domain superfamily Peptidase M10A Peptidase M10A, catalytic domain Peptidase M10A, cysteine switch, zinc binding site Peptidase M10, metallopeptidase Peptidase, metallopeptidase Peptidoglycan binding-like PGBD-like superfamily PGBD superfamily
UniProtKB:F1R3P5 475
UniProtKB:Q6P0J8 386
UniProtKB:Q7ZWD0 167
UniProtKB:B0JZI6 476
UniProtKB:F1QCX8 476
UniProtKB:Q71G59 475
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mmp13a polyclonal IgG Rabbit
AnaSpec
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations