Gene
foxi3b
- ID
- ZDB-GENE-031126-4
- Name
- forkhead box I3b
- Symbol
- foxi3b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within epidermal cell fate specification and ionocyte differentiation. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; integument; ionocyte; ionocyte progenitor cell; and yolk. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4. Orthologous to several human genes including FOXI1 (forkhead box I1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22519 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-foxi3b | N/A | Hsiao et al., 2007 |
| MO2-foxi3b | N/A | (3) |
| MO3-foxi3b | N/A | Esaki et al., 2009 |
| MO4-foxi3b | N/A | Esaki et al., 2009 |
| MO5-foxi3b | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Craniofacial microsomia 2 | 620444 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box domain-containing protein | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T1C0 | InterPro | 383 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxi3b-201
(1)
|
Ensembl | 1,865 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-foxi3b | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-232M8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193980 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193987 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198918 (1) | 1300 nt | ||
| Genomic | GenBank:BX248097 (2) | 171333 nt | ||
| Polypeptide | UniProtKB:Q7T1C0 (1) | 383 aa |
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Peloggia, J., Münch, D., Meneses-Giles, P., Romero-Carvajal, A., Lush, M.E., Lawson, N.D., McClain, M., Pan, Y.A., Piotrowski, T. (2021) Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes. Developmental Cell. 56(9):1296-1312.e7
- Tarashansky, A.J., Musser, J.M., Khariton, M., Li, P., Arendt, D., Quake, S.R., Wang, B. (2021) Mapping single-cell atlases throughout Metazoa unravels cell type evolution. eLIFE. 10:
- Dave, P.H., Kwong, R.W.M. (2020) Cadmium exposure reduces the density of a specific ionocyte subtype in developing zebrafish. Chemosphere. 244:125535
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Chen, Y.C., Liao, B.K., Lu, Y.F., Liu, Y.H., Hsieh, F.C., Hwang, P.P., Hwang, S.L. (2019) Zebrafish Klf4 maintains the ionocyte progenitor population by regulating epidermal stem cell proliferation and lateral inhibition. PLoS Genetics. 15:e1008058
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Shu, Y., Lou, Q., Dai, Z., Dai, X., He, J., Hu, W., Yin, Z. (2016) The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models. Scientific Reports. 6:18597
- Deng, C., Chen, H., Yang, N., Feng, Y., Hsueh, A.J. (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. The Journal of biological chemistry. 290(30):18261-8
- Chang, W.J., Wang, Y.F., Hu, H.J., Wang, J.H., Lee, T.H., and Hwang, P.P. (2013) Compensatory regulation of Na+ absorption by Na+/H+ exchanger and Na+-Cl- cotransporter in zebrafish (Danio rerio). Frontiers in Zoology. 10(1):46
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