ZFIN ID: ZDB-GENE-031114-3
Gene Name: Fli-1 proto-oncogene, ETS transcription factor-related sequence
Gene Symbol: fli1rs    Nomenclature History

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Previous Names: fli1b, zgc:5777174

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in angiogenesis; regulation of transcription, DNA-templated; and vasculogenesis. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Is expressed in endothelial cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor).
Genome Resources: Alliance (1),  Gene:386723 (1),  Ensembl(GRCz11):ENSDARG00000040080 (2)
Note: This gene is similar to Fli-1 proto-oncogene, ETS transcription factor, but analyses indicate that the ancestral gene was duplicated prior to the divergence of ray- and lobe-fin fishes and not the result of the WGD event in the ray-fin fishes, so the gene name has been updated to fli1rs to reflect this relationship.
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027761Tg Transgenic Insertion Unknown Unknown DNA
sa36230 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tpl50Gt Transgenic Insertion Intron 1 Unknown DNA
    tpl95Gt Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fli1rs N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fli1rs HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Bleeding disorder, platelet-type, 21 617443
    DISEASE ASSOCIATED WITH fli1rs VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component host cell nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fli1b-201 (1)    Ensembl 2704
    fli1b-203 (1)    Ensembl 2781
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-fli1b polyclonal Rabbit IHC Kerafast
    3
    CONSTRUCTS WITH SEQUENCES FROM fli1rs No data available
    MARKER RELATIONSHIPS
    fli1rs Contained in: [BAC] CH211-225P5 (1)
    fli1rs Encodes: [EST] IMAGE:5777174
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001008780 (1) 2804 nt
    Genomic GenBank:BX649388 (1) 177865 nt
    Select Tool
    Polypeptide UniProtKB:F1R5K9 (1) 467 aa
    Sequence Information (all 32)
    ORTHOLOGY for fli1rs ( Chr: 16 )
    CITATIONS (46)