Gene

fga

ID

ZDB-GENE-031010-21

Name

fibrinogen alpha chain

Symbol

fga Nomenclature History

Previous Names

sb:cb892
wu:fa55c12
wu:fb20e08
wu:fb59b03
wu:fi39d04
zgc:92117

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within blood coagulation, fibrin clot formation; platelet aggregation; and positive regulation of blood coagulation. Predicted to be located in extracellular region. Predicted to be part of fibrinogen complex. Is expressed in blood plasma; liver; and yolk syncytial layer. Used to study congenital afibrinogenemia and vascular hemostatic disease. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Orthologous to human FGA (fibrinogen alpha chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb892 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fga Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital afibrinogenemia	Alliance	Afibrinogenemia, congenital	202400
familial visceral amyloidosis	Alliance	Amyloidosis, hereditary systemic 2	105200
		Dysfibrinogenemia, congenital	616004
		Hypodysfibrinogenemia, congenital	616004

Associated With fga Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital afibrinogenemia	fga^ug703/ug703 (AB)	standard conditions	Fish et al., 2014
congenital afibrinogenemia	fga^ug701/ug701 (AB)	standard conditions	Fish et al., 2014
congenital afibrinogenemia	fga^ug702/ug702 (AB)	standard conditions	Fish et al., 2014
vascular hemostatic disease	fga^{mi4007/mi4007} (AB/TL)	standard conditions	Hu et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020837	Fibrinogen, conserved site
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Domain	IPR012290	Fibrinogen, alpha/beta/gamma chain, coiled coil domain
Family	IPR037579	Fibrinogen/angiopoietin-like
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal

Domain Details Per Protein

Protein	Additional Resources	Length	Fibrinogen, alpha/beta/gamma chain, coiled coil domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Fibrinogen/angiopoietin-like	Fibrinogen, conserved site	Fibrinogen-like, C-terminal
UniProtKB:B8A5L6	InterPro	684

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fga-201 (1) Ensembl	Ensembl	2,366 nt	Select Tool ZFIN BLAST
mRNA	fga-203 (1) Ensembl	Ensembl	2,469 nt	Select Tool ZFIN BLAST
ncRNA	fga-003 (1) Ensembl	Ensembl	690 nt	Select Tool ZFIN BLAST
ncRNA	fga-004 (1) Ensembl	Ensembl	768 nt	Select Tool ZFIN BLAST
ncRNA	fga-005 (1) Ensembl	Ensembl	751 nt	Select Tool ZFIN BLAST
ncRNA	fga-006 (1) Ensembl	Ensembl	503 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fga	polyclonal	fga	IgG	Rabbit	WB		3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations