Gene

fga

ID
ZDB-GENE-031010-21
Name
fibrinogen alpha chain
Symbol
fga Nomenclature History
Previous Names
  • sb:cb892
  • wu:fa55c12
  • wu:fb20e08
  • wu:fb59b03
  • wu:fi39d04
  • zgc:92117
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have signaling receptor binding activity. Involved in blood coagulation, fibrin clot formation. Predicted to localize to collagen-containing extracellular matrix and extracellular space. Is expressed in liver and yolk syncytial layer. Used to study vascular hemostatic disease. Human ortholog(s) of this gene implicated in congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Orthologous to human FGA (fibrinogen alpha chain).
Genome Resources
Note
None
Expression
All Expression Data
15 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Hu et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fga Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital afibrinogenemia Alliance Afibrinogenemia, congenital 202400
familial visceral amyloidosis Alliance Amyloidosis, familial visceral 105200
Dysfibrinogenemia, congenital 616004
Hypodysfibrinogenemia, congenital 616004
Associated With fga Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020837 Fibrinogen, conserved site
Domain IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Domain IPR012290 Fibrinogen, alpha/beta/gamma chain, coiled coil domain
Family IPR037579 Fibrinogen alpha chain
Homologous_superfamily IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
Homologous_superfamily IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily IPR036056 Fibrinogen-like, C-terminal
Domain Details Per Protein
Protein Length Fibrinogen, alpha/beta/gamma chain, coiled coil domain Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2 Fibrinogen alpha chain Fibrinogen, conserved site Fibrinogen-like, C-terminal
UniProtKB:E9QCD1 456
UniProtKB:B8A5L6 684
UniProtKB:Q6DHS2 684
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations