Gene
fga
- ID
- ZDB-GENE-031010-21
- Name
- fibrinogen alpha chain
- Symbol
- fga Nomenclature History
- Previous Names
-
- sb:cb892
- wu:fa55c12
- wu:fb20e08
- wu:fb59b03
- wu:fi39d04
- zgc:92117
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within blood coagulation, fibrin clot formation; platelet aggregation; and positive regulation of blood coagulation. Predicted to be located in extracellular region. Predicted to be part of fibrinogen complex. Is expressed in blood plasma; liver; and yolk syncytial layer. Used to study congenital afibrinogenemia and vascular hemostatic disease. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; familial visceral amyloidosis; and thrombophilia. Orthologous to human FGA (fibrinogen alpha chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb892 (5 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mi4007 | Allele with one insertion | Unknown | Unknown | TALEN | |
| sa651 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12469 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ug701 | Allele with one delins | Exon 2 | Unknown | zinc finger nuclease | |
| ug702 | Allele with one deletion | Exon 2 | Unknown | zinc finger nuclease | |
| ug703 | Allele with one deletion | Exon 2 | Unknown | zinc finger nuclease | |
| ug704 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| zko212a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fga | (2) | |
| CRISPR2-fga | Fish et al., 2021 | |
| MO1-fga | N/A | (4) |
| TALEN1-fga | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital afibrinogenemia | Alliance | Afibrinogenemia, congenital | 202400 |
| familial visceral amyloidosis | Alliance | Amyloidosis, hereditary systemic 2 | 105200 |
| Dysfibrinogenemia, congenital | 616004 | ||
| Hypodysfibrinogenemia, congenital | 616004 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020837 | Fibrinogen, conserved site |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Domain | IPR012290 | Fibrinogen, alpha/beta/gamma chain, coiled coil domain |
| Family | IPR037579 | Fibrinogen/angiopoietin-like |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, coiled coil domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen/angiopoietin-like | Fibrinogen, conserved site | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8A5L6 | InterPro | 684 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-75B4 | ZFIN Curated Data | |
| Encodes | EST | cb892 | Thisse et al., 2001 | |
| Encodes | EST | fa55c12 | ||
| Encodes | EST | fb20e08 | ||
| Encodes | EST | fb59b03 | ||
| Encodes | EST | fi39d04 | ||
| Encodes | cDNA | MGC:92117 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001194989 (1) | 2349 nt | ||
| Genomic | GenBank:BX548256 (2) | 181272 nt | ||
| Polypeptide | UniProtKB:B8A5L6 (1) | 684 aa |
- McCann, T., Sundaramurthi, H., Walsh, C., Virdi, S., Alvarez, Y., Sapetto-Rebow, B., Collery, R.F., Carter, S.P., Moran, A., Mulholland, R., O'Connor, J.J., Taylor, M.R., Rauch, N., Starostik, M.R., English, M.A., Swaroop, A., Geisler, R., Reynolds, A.L., Kennedy, B.N. (2024) Emc1 is essential for vision and zebrafish photoreceptor outer segment morphogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e70086e70086
- Zhang, H., Sun, C., Xia, Q., Li, P., Liu, K., Zhang, Y. (2024) Brevianamide F Exerts Antithrombotic Effects by Modulating the MAPK Signaling Pathway and Coagulation Cascade. Marine drugs. 22(10):
- Deng, Y., Han, X., Chen, H., Zhao, C., Chen, Y., Zhou, J., de The, H., Zhu, J., Yuan, H. (2023) Ypel5 regulates liver development and function in zebrafish. Journal of molecular cell biology. 15(3):
- Wang, N., Lan, C., Lu, H., Li, L., Liao, D., Xu, K., Sun, H., Tang, Y., Wang, Y., Mei, J., Wei, M., Wu, T., Zhu, H. (2023) Preventive effect and mechanism of Tibetan tea extract on thrombosis in arachidonic acid-induced zebrafish determined via RNA-seq transcriptome profiles. PLoS One. 18:e0285216e0285216
- Grzegorski, S.J., Zhao, Y., Richter, C.E., Ku, C.J., Lavik, K.I., Paul, D., Morrissey, J.H., Shavit, J.A. (2022) Genetic duplication of tissue factor reveals subfunctionalization in venous and arterial hemostasis. PLoS Genetics. 18:e1010534e1010534
- Zhang, Y., Ma, C., He, L., Liao, L., Guo, C., Wang, C., Gong, L., Zhou, H., Fu, K., Peng, C., Li, Y. (2022) Tetramethylpyrazine Protects Endothelial Injury and Antithrombosis via Antioxidant and Antiapoptosis in HUVECs and Zebrafish. Oxidative medicine and cellular longevity. 2022:2232365
- Fish, R.J., Freire, C., Di Sanza, C., Neerman-Arbez, M. (2021) Venous Thrombosis and Thrombocyte Activity in Zebrafish Models of Quantitative and Qualitative Fibrinogen Disorders. International Journal of Molecular Sciences. 22(2):
- Li, J., Liu, H., Yang, Z., Yu, Q., Zhao, L., Wang, Y. (2021) Synergistic Effects of Cryptotanshinone and Senkyunolide I in Guanxinning Tablet Against Endogenous Thrombus Formation in Zebrafish. Frontiers in pharmacology. 11:622787
- Liao, L., Zhou, M., Wang, J., Xue, X., Deng, Y., Zhao, X., Peng, C., Li, Y. (2021) Identification of the Antithrombotic Mechanism of Leonurine in Adrenalin Hydrochloride-Induced Thrombosis in Zebrafish via Regulating Oxidative Stress and Coagulation Cascade. Frontiers in pharmacology. 12:742954
- Ma, X., Chen, Y., Jiang, S., Zhao, X. (2021) A Bioassay-Based Approach for the Batch-To-Batch Consistency Evaluation of Xuesaitong Injection on a Zebrafish Thrombosis Model. Frontiers in pharmacology. 12:623533
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