Gene
lhx8a
- ID
- ZDB-GENE-031008-2
- Name
- LIM homeobox 8a
- Symbol
- lhx8a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in forebrain neuron development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain; dental mesenchyme; pharyngeal arch 1; and pharynx. Orthologous to human LHX8 (LIM homeobox 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb875 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox transcription factors | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BIF2 | InterPro | 328 | |||||
| UniProtKB:Q6BDC3 | InterPro | 332 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-189N19 | ZFIN Curated Data | |
| Encodes | EST | cb875 | Thisse et al., 2001 | |
| Encodes | EST | fk78g12 | ||
| Encodes | cDNA | MGC:136448 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003980 (1) | 1508 nt | ||
| Genomic | GenBank:BX901918 (2) | 171438 nt | ||
| Polypeptide | UniProtKB:Q6BDC3 (1) | 332 aa |
- Jackson, A., Lin, S.J., Jones, E.A., Chandler, K.E., Orr, D., Moss, C., Haider, Z., Ryan, G., Holden, S., Harrison, M., Burrows, N., Jones, W.D., Loveless, M., Petree, C., Stewart, H., Low, K., Donnelly, D., Lovell, S., Drosou, K., Genomics England Research Consortium, Solve-RD consortium, Varshney, G.K., Banka, S. (2023) Clinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14. HGG advances. 4:100186100186
- Ncube, D., Tallafuss, A., Serafin, J., Bruckner, J., Farnsworth, D.R., Miller, A.C., Eisen, J.S., Washbourne, P. (2022) A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior. BMC Genomics. 23:675
- Paudel, S., Gjorcheska, S., Bump, P., Barske, L. (2022) Patterning of cartilaginous condensations in the developing facial skeleton. Developmental Biology. 486:44-55
- Stednitz, S.J., McDermott, E.M., Ncube, D., Tallafuss, A., Eisen, J.S., and Washbourne, P. (2018) Forebrain Control of Behaviorally Driven Social Orienting in Zebrafish. Current biology : CB. 28(15):2445-2451.e3
- Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Fisher, A., Gemmell, N.J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics. 18:557
- Nakayama, Y., Inomata, C., Yuikawa, T., Tsuda, S., Yamasu, K. (2017) Comprehensive analysis of target genes in zebrafish embryos reveals gbx2 involvement in neurogenesis. Developmental Biology. 430(1):237-248
- Hulsey, C.D., Fraser, G.J., Meyer, A. (2016) Biting into the Genome to Phenome Map: Developmental Genetic Modularity of Cichlid Fish Dentitions. Integrative and Comparative Biology. 56(3):373-88
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Tallafuss, A., Kelly, M., Gay, L., Gibson, D., Batzel, P., Karfilis, K.V., Eisen, J., Stankunas, K., Postlethwait, J.H., Washbourne, P. (2015) Transcriptomes of post-mitotic neurons identify the usage of alternative pathways during adult and embryonic neuronal differentiation. BMC Genomics. 16:1100
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