Gene
hsp90b1
- ID
- ZDB-GENE-031002-1
- Name
- heat shock protein 90, beta (grp94), member 1
- Symbol
- hsp90b1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Acts upstream of or within defense response to Gram-positive bacterium; otolith tethering; and response to hypoxia. Predicted to be located in melanosome and sarcoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum and perinuclear region of cytoplasm. Is expressed in several structures, including axis; hatching gland; integument; lateral line system; and polster. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77624 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Mesquita et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hsp90b1 | N/A | Sumanas et al., 2003 |
| MO2-hsp90b1 | N/A | Sumanas et al., 2003 |
| MO3-hsp90b1 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019805 | Heat shock protein Hsp90, conserved site |
| Domain | IPR003594 | Histidine kinase/HSP90-like ATPase domain |
| Domain | IPR020575 | Heat shock protein Hsp90, N-terminal |
| Family | IPR001404 | Heat shock protein Hsp90 family |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Heat shock protein Hsp90, conserved site | Heat shock protein Hsp90 family | Heat shock protein Hsp90, N-terminal | Histidine kinase/HSP90-like ATPase domain | Histidine kinase/HSP90-like ATPase superfamily | HSP90, C-terminal domain | Ribosomal protein uS5 domain 2-type superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T3L3 | InterPro | 793 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsp90b1-201
(1)
|
Ensembl | 2,764 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-22L11 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-27E10 | ZFIN Curated Data | |
| Encodes | EST | fb61d09 | ||
| Encodes | EST | fq25g01 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:77624 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198210 (1) | 2758 nt | ||
| Genomic | GenBank:BX465859 (1) | 214205 nt | ||
| Polypeptide | UniProtKB:Q7T3L3 (1) | 793 aa |
- Fu, J.L., Zheng, S.Y., Wang, Y., Hu, X.B., Xiao, Y., Wang, J.M., Zhang, L., Wang, L., Nie, Q., Hou, M., Bai, Y.Y., Gan, Y.W., Liang, X.M., Xie, L.L., Li, D.W. (2023) HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221522120e2221522120
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Crouzier, L., Richard, E.M., Diez, C., Alzaeem, H., Denus, M., Cubedo, N., Delaunay, T., Glendenning, E., Baxendale, S., Liévens, J.C., Whitfield, T.T., Maurice, T., Delprat, B. (2022) Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines. Human molecular genetics. 31(16):2711-2727
- Crouzier, L., Richard, E.M., Diez, C., Denus, M., Peyrel, A., Alzaeem, H., Cubedo, N., Delaunay, T., Maurice, T., Delprat, B. (2022) NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome. Molecular therapy. Methods & clinical development. 27:295-308
- Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
- Shi, P., Liao, K., Xu, J., Wang, Y., Xu, S., Yan, X. (2022) Eicosapentaenoic acid mitigates palmitic acid-induced heat shock response, inflammation and repair processes in fish intestine. Fish & shellfish immunology. 124:362-371
- Wang, Z., Wang, X., Shi, L., Cai, Y., Hu, B. (2022) Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway. Acta neuropathologica communications. 10:184184
- Xiao, H., Wang, H., He, Q., Zhou, J., Du, S. (2022) Gene expression and functional analysis of Aha1a and Aha1b in stress response in zebrafish. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 262:110777
- Crouzier, L., Denus, M., Richard, E.M., Tavernier, A., Diez, C., Cubedo, N., Maurice, T., Delprat, B. (2021) Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish. International Journal of Molecular Sciences. 22(20):
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
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