ZFIN ID: ZDB-PUB-060825-17
Expression of the protein related to Dan and Cerberus gene—prdc—During eye, pharyngeal arch, somite, and swim bladder development in zebrafish
Muller, I.I., Knapik, E.W., and Hatzopoulos, A.K.
Date: 2006
Source: Developmental dynamics : an official publication of the American Association of Anatomists   235(10): 2881-2888 (Journal)
Registered Authors: Knapik, Ela W.
Keywords: prdc, BMP, zebrafish, eye, pharyngeal arches, swim bladder
MeSH Terms:
  • Air Sacs/embryology
  • Air Sacs/metabolism*
  • Amino Acid Sequence
  • Animals
  • Branchial Region/embryology
  • Branchial Region/metabolism*
  • Eye/embryology
  • Eye/metabolism*
  • Gene Expression Regulation, Developmental/genetics
  • In Situ Hybridization
  • Intercellular Signaling Peptides and Proteins/genetics*
  • Molecular Sequence Data
  • Phylogeny
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Homology, Amino Acid
  • Somites/enzymology
  • Somites/metabolism*
  • Zebrafish/embryology
  • Zebrafish/genetics*
  • Zebrafish Proteins/genetics*
PubMed: 16921498 Full text @ Dev. Dyn.
The protein related to Dan and Cerberus, or PRDC, is a secreted glycoprotein, which belongs to the DAN subfamily of bone morphogenetic protein (BMP) antagonists. In zebrafish, prdc is expressed initially around 17 hours postfertilization in the developing eyes and the first two pharyngeal arches. Expression in the eye starts in the outer layers of the optic cup. Later, prdc expression domains are juxtaposed at the edges of the optic cup surrounding the choroid fissure, then gradually becoming restricted to a small site in the ventral marginal zone. Prdc expression in the arch mesenchyme expands stepwise to the remaining posterior arches. Prdc is also detectable in the ventral part of the somites and the mesenchyme of the swim bladder. The relatively late appearance during development is a unique feature of Prdc among BMP antagonists. Moreover, the complexity of the prdc expression pattern suggests possible roles in eye development, pharyngeal arch remodeling, somitogenesis, and swim bladder organogenesis.