Gene
gabbr1a
- ID
- ZDB-GENE-030904-5
- Name
- gamma-aminobutyric acid (GABA) B receptor, 1a
- Symbol
- gabbr1a Nomenclature History
- Previous Names
-
- gaba1 (1)
- gabbr1
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Is expressed in female organism; male organism; and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with language delay and variable cognitive abnormalities | 620502 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000436 | Sushi/SCR/CCP domain |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR017978 | GPCR family 3, C-terminal |
| Family | IPR002455 | GPCR family 3, GABA-B receptor |
| Family | IPR002456 | GPCR family 3, gamma-aminobutyric acid receptor, type B1 |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
| Homologous_superfamily | IPR035976 | Sushi/SCR/CCP superfamily |
Domain Details Per Protein
| Protein | Length | GPCR family 3, C-terminal | GPCR family 3, GABA-B receptor | GPCR family 3, gamma-aminobutyric acid receptor, type B1 | Periplasmic binding protein-like I | Receptor, ligand binding region | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7UVF8
|
988 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gabbr1a-201
(1)
|
Ensembl | 3,179 nt | ||
| mRNA |
gabbr1a-202
(1)
|
Ensembl | 2,154 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gabbr1 | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available