Gene
gabbr1a
- ID
- ZDB-GENE-030904-5
- Name
- gamma-aminobutyric acid (GABA) B receptor, 1a
- Symbol
- gabbr1a Nomenclature History
- Previous Names
-
- gaba1 (1)
- gabbr1
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Is expressed in female organism; male organism; and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gabbr1a | Kuil et al., 2021 | |
| CRISPR2-gabbr1a | Guo et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with language delay and variable cognitive abnormalities | 620502 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR family 3, C-terminal | GPCR family 3, GABA-B receptor | GPCR family 3, gamma-aminobutyric acid receptor, type B1 | Periplasmic binding protein-like I | Receptor, ligand binding region | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7UVF8 | InterPro | 988 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gabbr1a-201
(1)
|
Ensembl | 3,179 nt | ||
| mRNA |
gabbr1a-202
(1)
|
Ensembl | 2,154 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gabbr1 | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:gabbr1a,Xla.Ef1a:EGFP) |
|
| Zebrafish Nomenclature Committee |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-108E8 | ZFIN Curated Data | |
| Contained in | BAC | CH73-314B22 | ZFIN Curated Data | |
| Contained in | BAC | CH211-231D1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-148A13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_689405 (1) | 4563 nt | ||
| Genomic | GenBank:BX629345 (1) | 133660 nt | ||
| Polypeptide | UniProtKB:A0A8N7UVF8 (1) | 988 aa |
- Guo, S., Gao, G., Zhang, C., Peng, G. (2022) Multiplexed Genome Editing for Efficient Phenotypic Screening in Zebrafish. Veterinary sciences. 9(2):
- Baker, M.R., Wong, R.Y. (2021) Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning. Scientific Reports. 11:12074
- Kuil, L.E., MacKenzie, K.C., Tang, C.S., Windster, J.D., Le, T.L., Karim, A., de Graaf, B.M., van der Helm, R., van Bever, Y., Sloots, C.E.J., Meeussen, C., Tibboel, D., de Klein, A., Wijnen, R.M.H., Amiel, J., Lyonnet, S., Garcia-Barcelo, M.M., Tam, P.K.H., Alves, M.M., Brooks, A.S., Hofstra, R.M.W., Brosens, E. (2021) Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. PLoS Genetics. 17:e1009698
- Manchanda, A., Bonventre, J.A., Bugel, S.M., Chatterjee, P., Tanguay, R., Johnson, C.P. (2021) Truncation of the otoferlin transmembrane domain alters the development of hair cells and reduces membrane docking. Molecular biology of the cell. 32(14):1293-1305
- Zaupa, M., Naini, S.M.A., Younes, M.A., Bullier, E., Duboué, E.R., Le Corronc, H., Soula, H., Wolf, S., Candelier, R., Legendre, P., Halpern, M.E., Mangin, J.M., Hong, E. (2021) Trans-inhibition of axon terminals underlies competition in the habenulo-interpeduncular pathway. Current biology : CB. 31(21):4762-4772.e5
- Mi, X., Li, Z., Yan, J., Li, Y., Zheng, J., Zhaung, Z., Yang, W., Gong, L., Shi, J. (2020) Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Biochimica et biophysica acta. Molecular basis of disease. 1866(10):165842
- Paiva, I.M., de Carvalho, L.M., Di Chiaccio, I.M., de Lima Assis, I., Sánchez, E.N., Garcia, M.B., Ferreira, F.N.A., Cayuela, M.L., Murgas, L.D.S., Godard, A.L.B. (2020) Inhibition of Lrrk2 reduces ethanol preference in a model of acute exposure in zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 100:109885
- Paiva, I.M., Sartori, B.M., Castro, T.F.D., Lunkes, L.C., Virote, B.D.C.R., Murgas, L.D.S., de Souza, R.P., Brunialti-Godard, A.L. (2020) Behavioral plasticity and gene regulation in the brain during an intermittent ethanol exposure in adult zebrafish population. Pharmacology, biochemistry, and behavior. 192:172909
- Pípal, M., Legradi, J., Smutná, M., Kočí, T., Priebojová, J., Bláhová, L., Krauss, M., Hilscherová, K. (2020) Neurobehavioral effects of cyanobacterial biomass field extracts on zebrafish embryos and potential role of retinoids. Aquatic toxicology (Amsterdam, Netherlands). 228:105613
- Shen, C., Zhou, Y., Tang, C., He, C., Zuo, Z. (2020) Developmental exposure to mepanipyrim induces locomotor hyperactivity in zebrafish (Danio rerio) larvae. Chemosphere. 256:127106
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