Gene
grk7b
- ID
- ZDB-GENE-030904-3
- Name
- G protein-coupled receptor kinase 7b
- Symbol
- grk7b Nomenclature History
- Previous Names
-
- gprk7
- grk7-2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables rhodopsin kinase activity. Predicted to be involved in regulation of signal transduction. Predicted to act upstream of or within protein phosphorylation; signal transduction; and visual perception. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in brain and visual system. Orthologous to human GRK7 (G protein-coupled receptor kinase 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-grk7b | N/A | Shen et al., 2021 |
| MO2-grk7b | N/A | Shen et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | GPCR kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 2 | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q49HM8 | InterPro | 548 | |||||||||
| UniProtKB:Q1XHL7 | InterPro | 548 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-20H16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193750 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193763 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001033090 (1) | 1797 nt | ||
| Genomic | GenBank:CU459064 (1) | 113310 nt | ||
| Polypeptide | UniProtKB:Q1XHL7 (1) | 548 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | GRK7 | 3 | Amino acid sequence comparison (2) |
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Liu, X., Han, S., Liu, F., Yu, S., Qin, Y., Li, J., Jia, D., Gao, P., Chen, X., Tang, Z., Liu, M., Huang, Y. (2023) Retinal degeneration in rpgra mutant zebrafish. Frontiers in cell and developmental biology. 11:11699411169941
- Lin, S.J., Vona, B., Barbalho, P.G., Kaiyrzhanov, R., Maroofian, R., Petree, C., Severino, M., Stanley, V., Varshney, P., Bahena, P., Alzahrani, F., Alhashem, A., Pagnamenta, A.T., Aubertin, G., Estrada-Veras, J.I., Hernández, H.A.D., Mazaheri, N., Oza, A., Thies, J., Renaud, D.L., Dugad, S., McEvoy, J., Sultan, T., Pais, L.S., Tabarki, B., Villalobos-Ramirez, D., Rad, A., Genomics England Research Consortium, Galehdari, H., Ashrafzadeh, F., Sahebzamani, A., Saeidi, K., Torti, E., Elloumi, H.Z., Mora, S., Palculict, T.B., Yang, H., Wren, J.D., Ben Fowler, ., Joshi, M., Behra, M., Burgess, S.M., Nath, S.K., Hanna, M.G., Kenna, M., Merritt, J.L., Houlden, H., Karimiani, E.G., Zaki, M.S., Haaf, T., Alkuraya, F.S., Gleeson, J.G., Varshney, G.K. (2021) Biallelic variants in KARS1 are associated with neurodevelopmental disorders and hearing loss recapitulated by the knockout zebrafish. Genetics in medicine : official journal of the American College of Medical Genetics. 23(10):1933-1943
- Ogawa, Y., Corbo, J.C. (2021) Partitioning of gene expression among zebrafish photoreceptor subtypes. Scientific Reports. 11:17340
- Shen, B., Wada, S., Nishioka, H., Nagata, T., Kawano-Yamashita, E., Koyanagi, M., Terakita, A. (2021) Functional identification of an opsin kinase underlying inactivation of the pineal bistable opsin parapinopsin in zebrafish. Zoological letters. 7:1
- Zang, J., Gesemann, M., Keim, J., Samardzija, M., Grimm, C., Neuhauss, S.C. (2021) Circadian regulation of vertebrate cone photoreceptor function. eLIFE. 10:
- Ahrens, N., Elbers, D., Greb, H., Janssen-Bienhold, U., Koch, K.W. (2020) Interaction of G protein-coupled receptor kinases and recoverin isoforms is determined by localization in zebrafish photoreceptors. Biochimica et biophysica acta. Molecular cell research. 1868(4):118946
- Li, Y., Zhang, J. (2020) The Effect of Acute Erythromycin Exposure on the Swimming Ability of Zebrafish (Danio rerio) and Medaka (Oryzias latipes). International Journal of Environmental Research and Public Health. 17(10):
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
- Chrispell, J.D., Dong, E., Osawa, S., Liu, J., Cameron, D.J., Weiss, E.R. (2018) Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish. Investigative ophthalmology & visual science. 59:5116-5124
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