Gene
slc2a8
- ID
- ZDB-GENE-030829-25
- Name
- solute carrier family 2 member 8
- Symbol
- slc2a8 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable D-glucose transmembrane transporter activity. Predicted to be involved in D-glucose transmembrane transport. Predicted to act upstream of or within transmembrane transport. Predicted to be active in membrane. Is expressed in several structures, including gill; muscle; nervous system; pericardial region; and pleuroperitoneal region. Orthologous to human SLC2A8 (solute carrier family 2 member 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb753 (15 images)
- cb808 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR005829 | Sugar transporter, conserved site |
| Domain | IPR020846 | Major facilitator superfamily domain |
| Family | IPR003663 | Sugar/inositol transporter |
| Family | IPR005828 | Major facilitator, sugar transporter-like |
| Family | IPR050549 | Major Facilitator Superfamily Trehalose Transporter |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Major facilitator, sugar transporter-like | Major facilitator superfamily domain | Major Facilitator Superfamily Trehalose Transporter | MFS transporter superfamily | Sugar/inositol transporter | Sugar transporter, conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZWH3 | InterPro | 498 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc2a8-201
(1)
|
Ensembl | 1,917 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-272F14 | ZFIN Curated Data | |
| Encodes | EST | cb753 | Thisse et al., 2001 | |
| Encodes | EST | cb808 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:56364 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212798 (1) | 1929 nt | ||
| Genomic | GenBank:BX927256 (1) | 51445 nt | ||
| Polypeptide | UniProtKB:Q7ZWH3 (1) | 498 aa |
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Tabler, C.T., Lodd, E., Bennewitz, K., Middel, C.S., Erben, V., Ott, H., Poth, T., Fleming, T., Morgenstern, J., Hausser, I., Sticht, C., Poschet, G., Szendroedi, J., Nawroth, P.P., Kroll, J. (2022) Loss of glyoxalase 2 alters the glucose metabolism in zebrafish. Redox Biology. 59:102576102576
- Michel, M., Page-McCaw, P.S., Chen, W., Cone, R.D. (2016) Leptin signaling regulates glucose homeostasis, but not adipostasis, in the zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 113(11):3084-9
- Cruz, S.A., Tseng, Y.C., Kaiya, H., Hwang, P.P., Cruz, S.A., Hwang, P.P., Kaiya, H., Tseng, Y.C., and Hwang, P.P. (2010) Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 156(2):190-200
- Tseng, Y.C., Chen, R.D., Lee, J.R., Liu, S.T., Lee, S.J., and Hwang, P.P. (2009) Specific Expression and Regulation of Glucose Transporters in Zebrafish Ionocytes. American journal of physiology. Regulatory, integrative and comparative physiology. 297(2):R275-R290
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 7 of 7
Show