Gene
hes6
- ID
- ZDB-GENE-030828-5
- Name
- hes family bHLH transcription factor 6
- Symbol
- hes6 Nomenclature History
- Previous Names
-
- her13.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables identical protein binding activity and protein heterodimerization activity. Acts upstream of or within negative regulation of DNA-templated transcription and somitogenesis. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including eye; margin; optic vesicle; pectoral fin; and segmental plate. Orthologous to human HES6 (hes family bHLH transcription factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77269 (14 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ki146Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| zf2172 | Allele with one deletion | Unknown | Unknown | TALEN | |
| zm00012575Tg | Transgenic insertion | Exon 1 | Premature Stop | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hes6 | Mi et al., 2023 | |
| MO1-hes6 | N/A | (5) |
| MO2-hes6 | N/A | Kawamura et al., 2005 |
| MO3-hes6 | N/A | (2) |
| TALEN1-hes6 | LLeras Forero et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Hairy and Enhancer of Split/HEY-related | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Orange domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q6P0J1 | InterPro | 226 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hes6-hsp70l:EGFP-SV40) |
|
| 1 | Kawamura et al., 2016 | |
| Tg(hes6-hsp70l:EGFP-UTR-her1) |
|
| 1 | Fujino et al., 2018 | |
| Tg(hes6-hsp70l:EGFP-UTR-her7) |
|
| 1 | Fujino et al., 2018 | |
| Tg(hes6-hsp70l:EGFP-UTR-hes6) |
|
| 1 | (2) | |
| Tg(hes6-hsp70l:EGFP-UTR-hes6-SV40) |
|
| 1 | Kawamura et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195J11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65903 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77269 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194400 (1) | 1294 nt | ||
| Genomic | GenBank:BX890608 (2) | 194388 nt | ||
| Polypeptide | UniProtKB:Q6P0J1 (1) | 226 aa |
- Chen, Y.C., Hsieh, F.Y., Chang, C.W., Sun, M.Q., Cheng, Y.C. (2024) Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment. International Journal of Molecular Sciences. 25(17):
- Mi, J., Liu, K.C., Andersson, O. (2023) Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish. Science advances. 9:eadf5142
- Yabe, T., Uriu, K., Takada, S. (2023) Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. Nature communications. 14:21152115
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Mizoguchi, T., Fukada, M., Iihama, M., Song, X., Fukagawa, S., Kuwabara, S., Omaru, S., Higashijima, S.I., Itoh, M. (2020) Transient activation of the Notch-her15.1 axis plays an important role in the maturation of V2b interneurons. Development (Cambridge, England). 147(16):
- Xu, B., Tang, X., Jin, M., Zhang, H., Du, L., Yu, S., He, J. (2020) Unifying Developmental Programs for Embryonic and Post-Embryonic Neurogenesis in the Zebrafish Retina. Development (Cambridge, England). 147(12):
- Fujino, Y., Yamada, K., Sugaya, C., Ooka, Y., Ovara, H., Ban, H., Akama, K., Otosaka, S., Kinoshita, H., Yamasu, K., Mishima, Y., Kawamura, A. (2018) Deadenylation by the CCR4-NOT complex contributes to the turnover of hairy-related mRNAs in the zebrafish segmentation clock. FEBS letters. 592(20):3388-3398
- LLeras Forero, L., Narayanan, R., Huitema, L.F.A., VanBergen, M., Apschner, A., Peterson-Maduro, J., Logister, I., Valentin, G., Morelli, L.G., Oates, A., Schulte-Merker, S. (2018) Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock. eLIFE. 7
- Chen, K.W., Liao, K.L., Shih, C.W. (2017) The kinetics in mathematical models on segmentation clock genes in zebrafish. Journal of mathematical biology. 76(1-2):97-150
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