ZFIN ID: ZDB-GENE-030828-5
Gene Name: hes family bHLH transcription factor 6
Gene Symbol: hes6    Nomenclature History

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Previous Name: her13.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in negative regulation of transcription, DNA-templated and somitogenesis. Predicted to localize to nucleus. Is expressed in several structures, including eye; margin; optic vesicle; pectoral fin; and segmental plate. Orthologous to human HES6 (hes family bHLH transcription factor 6).
Genome Resources: Alliance (1),  Gene:373116 (1),  Ensembl(GRCz11):ENSDARG00000019335 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
zf2172 Small Deletion Unknown Unknown TALEN
zm00012575Tg Transgenic Insertion Exon 1 Premature Stop DNA
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-hes6 N/A 5
MO2-hes6 N/A 1
MO3-hes6 N/A 2
TALEN1-hes6 1
DISEASE ASSOCIATED WITH hes6 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH hes6 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of transcription, DNA-templated (more)
Cellular Component transcription repressor complex (more)
Molecular Function protein heterodimerization activity (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hes6-201 (1)    Ensembl 1264
hes6-203 (1)    Ensembl 559
ncRNA hes6-002 (1)    Ensembl 625
hes6-003 (1)    Ensembl 794
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hes6
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(hes6-hsp70l:EGFP-SV40) hes6hsp70l EGFP Danio rerio 1 1
tg(hes6-hsp70l:egfp-utr-her1) hes6hsp70l EGFPher1UTR Danio rerio 1 1
tg(hes6-hsp70l:egfp-utr-her7) hes6hsp70l EGFPher7UTR Danio rerio 1 1
Tg(hes6-hsp70l:EGFP-UTR-hes6) hes6hsp70l EGFPhes6UTR Danio rerio 1 2
Tg(hes6-hsp70l:EGFP-UTR-hes6-SV40) hes6hsp70l EGFPhes6UTR Danio rerio 1 1
MARKER RELATIONSHIPS
hes6 Contained in: [BAC] CH211-195J11 (1)
hes6 Encodes: [cDNA] MGC:65903 (1), MGC:77269 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_194400 (1) 1294 nt
Genomic GenBank:BX890608 (1) 194388 nt
Select Tool
Polypeptide UniProtKB:F1QMG5 (1) 226 aa
Sequence Information (all 18)
ORTHOLOGY for hes6 ( Chr: 2 )
CITATIONS (53)