ZFIN Gene: hes6

ZFIN ID: ZDB-GENE-030828-5

ZFIN ID: ZDB-GENE-030828-5

Gene Name:

hes family bHLH transcription factor 6

Gene Symbol:

hes6 Nomenclature History

Previous Name:

her13.2 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 2 Mapping Details/Browsers

Description:

Exhibits protein heterodimerization activity. Involved in negative regulation of transcription, DNA-templated and somitogenesis. Predicted to localize to nucleus. Is expressed in several structures, including eye; margin; optic vesicle; pectoral fin; and segmental plate. Orthologous to human HES6 (hes family bHLH transcription factor 6).

Genome Resources:

Alliance (1), Gene:373116 (1), Ensembl(GRCz11):ENSDARG00000019335 (2)

GENE EXPRESSION
All Expression Data:	18 figures from 12 publications
Directly Submitted Expression Data:	6 figures (14 images) from Thisse et al., 2004 [MGC:77269]
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
	central nervous system eye gill head heart liver margin mesenchyme pectoral fin neural rod optic vesicle pectoral fin retina segmental plate somite tail bud anterior-posterior gradient tail bud telencephalon testis unspecified
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
zf2172	Small Deletion	Unknown	Unknown	TALEN
zm00012575Tg	Transgenic Insertion	Exon 1	Premature Stop	DNA

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-hes6	N/A	5
MO2-hes6	N/A	1
MO3-hes6	N/A	2
TALEN1-hes6	zf2172	1

PHENOTYPE

Data:	4 figures from 2 publications
Observed in:	anal fin centrum dorsal fin hemal arch myotome postcranial axial skeleton posterior region proctodeum somite anterior-posterior axis somitogenesis trunk vertebra vertebral column

DISEASE ASSOCIATED WITH hes6 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH hes6 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	negative regulation of transcription, DNA-templated (more)
Cellular Component	transcription repressor complex (more)
Molecular Function	protein heterodimerization activity (more)

GO Terms (all 13)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	hes6-201 (1)	1264	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	hes6-203 (1)	559	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	hes6-002 (1)	625	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	hes6-003 (1)	794	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM hes6

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(hes6-hsp70l:EGFP-SV40)	hes6, hsp70l	EGFP	Danio rerio	1	1
tg(hes6-hsp70l:egfp-utr-her1)	hes6, hsp70l	EGFP, her1, UTR	Danio rerio	1	1
tg(hes6-hsp70l:egfp-utr-her7)	hes6, hsp70l	EGFP, her7, UTR	Danio rerio	1	1
Tg(hes6-hsp70l:EGFP-UTR-hes6)	hes6, hsp70l	EGFP, hes6, UTR	Danio rerio	1	2
Tg(hes6-hsp70l:EGFP-UTR-hes6-SV40)	hes6, hsp70l	EGFP, hes6, UTR	Danio rerio	1	1

MARKER RELATIONSHIPS

hes6 Contained in:	[BAC] CH211-195J11 (1)
hes6 Encodes:	[cDNA] MGC:65903 (1), MGC:77269 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_194400 (1)	1294 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX890608 (1)	194388 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1QMG5 (1)	226 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 18)

ORTHOLOGY for hes6 ( Chr: 2 )

CITATIONS (53)

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