ZFIN ID: ZDB-PUB-050523-9
Zebrafish Hairy/Enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites
Kawamura, A., Koshida, S., Hijikata, H., Sakaguchi, T., Kondoh, H., and Takada, S.
Date: 2005
Source: Genes & Development   19(10): 1156-1161 (Journal)
Registered Authors: Kawamura, Akinori, Kondoh, Hisato, Koshida, Sumito, Sakaguchi, Takuya, Takada, Shinji
Keywords: Somite segmentation; FGF signaling; cyclic gene expression; hairy/Espl; negative feedback loop; zebrafish
MeSH Terms:
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Body Patterning/genetics
  • Body Patterning/physiology*
  • Fibroblast Growth Factors/metabolism
  • Fibroblast Growth Factors/pharmacology
  • Gene Expression Regulation, Developmental/genetics
  • Gene Expression Regulation, Developmental/physiology*
  • Signal Transduction/genetics
  • Signal Transduction/physiology*
  • Somites/metabolism*
  • Transcription Factors/biosynthesis
  • Transcription Factors/genetics
  • Transcription Factors/metabolism*
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins/biosynthesis
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 15905406 Full text @ Genes & Dev.
Notch and fibroblast growth factor (FGF) signaling pathways have been implicated in the establishment of proper periodicity of vertebrate somites. Here, we show evidence that a Hes6-related hairy/Enhancer of split-related gene, her13.2, links FGF signaling to the Notch-regulated oscillation machinery in zebrafish. Expression of her13.2 is induced by FGF-soaked beads and decreased by an FGF signaling inhibitor. her13.2 is required for periodic repression of the Notch-regulated genes her1 and her7, and for proper somite segmentation. Furthermore, Her13.2 augments autorepression of her1 in association with Her1 protein. Therefore, FGF signaling appears to maintain the oscillation machinery by supplying a binding partner, Her13.2, for Her1.