PUBLICATION

Zebrafish Hairy/Enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites

Authors
Kawamura, A., Koshida, S., Hijikata, H., Sakaguchi, T., Kondoh, H., and Takada, S.
ID
ZDB-PUB-050523-9
Date
2005
Source
Genes & Development   19(10): 1156-1161 (Journal)
Registered Authors
Kawamura, Akinori, Kondoh, Hisato, Koshida, Sumito, Sakaguchi, Takuya, Takada, Shinji
Keywords
Somite segmentation; FGF signaling; cyclic gene expression; hairy/Espl; negative feedback loop; zebrafish
MeSH Terms
  • Transcription Factors/biosynthesis
  • Transcription Factors/genetics
  • Transcription Factors/metabolism*
  • Signal Transduction/genetics
  • Signal Transduction/physiology*
  • Somites/metabolism*
  • Zebrafish Proteins/biosynthesis
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • Gene Expression Regulation, Developmental/genetics
  • Gene Expression Regulation, Developmental/physiology*
  • Fibroblast Growth Factors/metabolism
  • Fibroblast Growth Factors/pharmacology
  • Basic Helix-Loop-Helix Transcription Factors
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Animals
  • Body Patterning/genetics
  • Body Patterning/physiology*
(all 19)
PubMed
15905406 Full text @ Genes & Dev.
Abstract
Notch and fibroblast growth factor (FGF) signaling pathways have been implicated in the establishment of proper periodicity of vertebrate somites. Here, we show evidence that a Hes6-related hairy/Enhancer of split-related gene, her13.2, links FGF signaling to the Notch-regulated oscillation machinery in zebrafish. Expression of her13.2 is induced by FGF-soaked beads and decreased by an FGF signaling inhibitor. her13.2 is required for periodic repression of the Notch-regulated genes her1 and her7, and for proper somite segmentation. Furthermore, Her13.2 augments autorepression of her1 in association with Her1 protein. Therefore, FGF signaling appears to maintain the oscillation machinery by supplying a binding partner, Her13.2, for Her1.
Genes / Markers
Figures
Figure Gallery (5 images)
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Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
ti1
    		Small Deletion
    tr233
      		Point Mutation
      1 - 2 of 2
      Show
      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      Target Reagent Reagent Type
      hes6MO1-hes6MRPHLNO
      hes6MO2-hes6MRPHLNO
      1 - 2 of 2
      Show
      Fish
      Fish
      dldtr233/tr233
      tbx6ti1/ti1
      WT
      WT + MO1-hes6 + MO2-hes6
      1 - 4 of 4
      Show
      Antibodies
      No data available
      Orthology
      No data available
      Engineered Foreign Genes
      No data available
      Mapping
      No data available
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      Citation
      Kawamura, A., Koshida, S., Hijikata, H., Sakaguchi, T., Kondoh, H., and Takada, S. (2005) Zebrafish Hairy/Enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites. Genes & Development. 19(10):1156-1161.