Gene
birc5a
- ID
- ZDB-GENE-030826-1
- Name
- baculoviral IAP repeat containing 5a
- Symbol
- birc5a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of angiogenesis; and regulation of apoptotic process. Predicted to be located in chromosome, centromeric region and spindle. Predicted to be active in cytoplasm and nucleus. Is expressed in axial vasculature; brain; and central nervous system. Human ortholog(s) of this gene implicated in prostate cancer; pulmonary hypertension; and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-birc5a | N/A | (5) |
| MO2-birc5a | N/A | (2) |
| MO3-birc5a | N/A | Ma et al., 2007 |
| MO4-birc5a | N/A | Delvaeye et al., 2009 |
| MO5-birc5a | N/A | Delvaeye et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Baculoviral IAP repeat-containing | BIR repeat |
|---|---|---|---|---|
| UniProtKB:Q90WU9 | InterPro | 142 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
birc5a-201
(1)
|
Ensembl | 1,471 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-369D14 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-92C5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66070 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194397 (1) | 1204 nt | ||
| Genomic | GenBank:CR932362 (2) | 157329 nt | ||
| Polypeptide | UniProtKB:Q90WU9 (1) | 142 aa |
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Liu, C.C., Shih, T.C., Pai, T.W., Hu, C.H., Tzou, W.S. (2021) Enhanced Over-Representation Analysis for the Differential Regulation of Birc5a and HIF2α-Knockdown Approaches. Journal of computational biology : a journal of computational molecular cell biology. 28(7):674-686
- Qi, Z., Yan, D., Cao, L., Xu, Y., Chang, M. (2021) Zebrafish BID Exerts an Antibacterial Role by Negatively Regulating p53, but in a Caspase-8-Independent Manner. Frontiers in immunology. 12:707426
- Lin, Y.C., Wu, C.Y., Hu, C.H., Pai, T.W., Chen, Y.R., Wang, W.D. (2020) Integrated Hypoxia Signaling and Oxidative Stress in Developmental Neurotoxicity of Benzo[a]Pyrene in Zebrafish Embryos. Antioxidants (Basel, Switzerland). 9(8)
- Hung, K.S., Hsiao, C.C., Pai, T.W., Hu, C.H., Tzou, W.S., Wang, W.D., Chen, Y.R. (2018) Functional enrichment analysis based on long noncoding RNA associations. BMC systems biology. 12:45
- Sarasquete, C., Úbeda-Manzanaro, M., Ortiz-Delgado, J.B. (2018) Toxicity and non-harmful effects of the soya isoflavones, genistein and daidzein, in embryos of the zebrafish, Danio rerio. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 211:57-67
- Liu, Y., Sepich, D.S., Solnica-Krezel, L. (2017) Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation. PLoS Genetics. 13:e1006564
- Mayrhofer, M., Gourain, V., Reischl, M., Affaticati, P., Jenett, A., Joly, J.S., Benelli, M., Demichelis, F., Poliani, P.L., Sieger, D., Mione, M. (2017) A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth. Disease models & mechanisms. 10(1):15-28
- Packard, R.R.S., Baek, K.I., Beebe, T., Jen, N., Ding, Y., Shi, F., Fei, P., Kang, B.J., Chen, P.H., Gau, J., Chen, M., Tang, J.Y., Shih, Y.H., Ding, Y., Li, D., Xu, X., Hsiai, T.K. (2017) Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Scientific Reports. 7:8603
- Luzio, A., Matos, M., Santos, D., Fontaínhas-Fernandes, A.A., Monteiro, S.M., Coimbra, A.M. (2016) Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures. Aquatic toxicology (Amsterdam, Netherlands). 177:269-284
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