Gene
xiap
- ID
- ZDB-GENE-030825-7
- Name
- X-linked inhibitor of apoptosis
- Symbol
- xiap Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; and positive regulation of protein ubiquitination. Predicted to act upstream of or within Wnt signaling pathway and apoptotic process. Predicted to be active in cytoplasm and nucleus. Is expressed in female organism; male organism; and testis. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| X-linked lymphoproliferative syndrome 2 | Alliance | Lymphoproliferative syndrome, X-linked, 2 | 300635 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BIR repeat | Inhibitor of Apoptosis | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|
| UniProtKB:A2RV08 | InterPro | 405 |
Interactions and Pathways
No data available
Plasmids
No data available