Gene
stat5a
- ID
- ZDB-GENE-030820-2
- Name
- signal transducer and activator of transcription 5a
- Symbol
- stat5a Nomenclature History
- Previous Names
-
- stat5.1
- stat5b
- sb:eu615
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway via JAK-STAT; hemopoiesis; and regulation of hemopoiesis. Predicted to be located in cytosol. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adaxial cell; female organism; liver; and telencephalon. Used to study growth hormone insensitivity syndrome with immune dysregulation 1. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; growth hormone insensitivity syndrome with immune dysregulation 1; and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu615 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb393 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb394 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| mdu022 | Allele with one insertion | Exon 5 | Unknown | CRISPR | |
| mdu032 | Allele with one deletion | Unknown | Inframe Deletion | CRISPR | |
| mdu033 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| sa10709 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19972 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33126 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40029 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tpl4Gt | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-stat5a | (2) | |
| CRISPR2-stat5a | (3) | |
| CRISPR3-stat5a | Awasthi et al., 2023 | |
| CRISPR4-stat5a | Emmerich et al., 2023 | |
| CRISPR5-stat5a | Emmerich et al., 2023 | |
| CRISPR6-stat5a | Emmerich et al., 2023 | |
| MO1-stat5a | N/A | Paffett-Lugassy et al., 2007 |
| MO2-stat5a | N/A | (2) |
| MO3-stat5a | N/A | (5) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| growth hormone insensitivity syndrome with immune dysregulation 1 | Alliance | Growth hormone insensitivity with immune dysregulation 1, autosomal recessive | 245590 |
| growth hormone insensitivity syndrome with immune dysregulation 2 | Alliance | Growth hormone insensitivity with immune dysregulation 2, autosomal dominant | 618985 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| growth hormone insensitivity syndrome with immune dysregulation 1 | stat5amdu022/mdu022 | standard conditions | Heidary et al., 2023 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | EF-hand domain pair | p53-like transcription factor, DNA-binding domain superfamily | PH-like domain superfamily | Phosphatidylinositol-specific phospholipase C, X domain | Phosphoinositide phospholipase C family | Phosphoinositide-specific phospholipase C, EF-hand-like domain | Phospholipase C, phosphatidylinositol-specific, Y domain | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily | Pleckstrin homology domain | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT5a/5b, coiled-coil domain | STAT5a/5b, DNA-binding domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q68SP3 | InterPro | 785 | |||||||||||||||||||||||
| UniProtKB:A0AB32TFF3 | InterPro | 1913 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
stat5a-201
(1)
|
Ensembl | 2,612 nt | ||
| mRNA |
stat5a-202
(1)
|
Ensembl | 880 nt |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-271G12 | ZFIN Curated Data | |
| Contained in | BAC | CH73-343F10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-272F19 | ZFIN Curated Data | |
| Encodes | EST | eu615 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193856 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194387 (1) | 2802 nt | ||
| Genomic | RefSeq:NW_018394526 (1) | 199941 nt | ||
| Polypeptide | UniProtKB:A0AB32TFF3 (1) | 1913 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | STAT5A | 17 | Amino acid sequence comparison (1) Conserved genome location (synteny) (1) | |
| Human | STAT5B | 17 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) | |
| Mouse | Stat5a | 11 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) | |
| Mouse | Stat5b | 11 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) |
- Awasthi, N., Ward, A.C., Liongue, C. (2023) Analysis of Potential Non-Canonical or Alternate STAT5 Functions in Immune Development and Growth. Frontiers in bioscience (Landmark edition). 28:187187
- Emmerich, K., Walker, S.L., Wang, G., White, D.T., Ceisel, A., Wang, F., Teng, Y., Chunawala, Z., Graziano, G., Nimmagadda, S., Saxena, M.T., Qian, J., Mumm, J.S. (2023) Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses. PLoS Genetics. 19:e1010905e1010905
- Heidary, S., Awasthi, N., Page, N., Allnutt, T., Lewis, R.S., Liongue, C., Ward, A.C. (2023) A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1). Cellular and molecular life sciences : CMLS. 80:109109
- Landi, E., Karabatas, L., Gómez, T.R., Salatino, L., Scaglia, P., Ramírez, L., Keselman, A., Braslavsky, D., Sanguineti, N., Pennisi, P., Rey, R.A., Bergadá, I., Jasper, H.G., Domené, H.M., Plazas, P.V., Domené, S. (2023) An in vivo functional assay to characterize human STAT5B genetic variants during zebrafish development. Human molecular genetics. 32(15):2473-2484
- Basheer, F., Bulleeraz, V., Ngo, V.Q.T., Liongue, C., Ward, A.C. (2022) In vivo impact of JAK3 A573V mutation revealed using zebrafish. Cellular and molecular life sciences : CMLS. 79:322
- Hsu, P.J., Wang, H.D., Tseng, Y.C., Pan, S.W., Sampurna, B.P., Jong, Y.J., Yuh, C.H. (2021) L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Journal of Biomedical Science. 28:8
- Wang, W.Q., Qiu, S.W., Huang, S.S., Wang, G.J., Han, M.Y., Kang, D.Y., Yuan, Y.Y., Gao, X., Dai, P. (2021) Transcriptome analysis of the early stage ifnlr1-mutant zebrafish indicates the immune response to auditory dysfunction. Gene expression patterns : GEP. 43:119229
- Peron, M., Dinarello, A., Meneghetti, G., Martorano, L., Facchinello, N., Vettori, A., Licciardello, G., Tiso, N., Argenton, F. (2020) The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent. Development (Cambridge, England). 147(12):
- Tu, J., Liu, X., Jia, H., Reilly, J., Yu, S., Cai, C., Liu, F., Lv, Y., Huang, Y., Lu, Z., Han, S., Jiang, T., Shu, X., Wu, X., Tang, Z., Lu, Q., Liu, M. (2020) The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(9):11997-12008
- Breves, J.P. (2018) Prolactin controls branchial clcn2c but not atp1a1a.2 in zebrafish Danio rerio. Journal of Fish Biology. 94(1):168-172
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