Gene
zar1
- ID
- ZDB-GENE-030818-1
- Name
- zygote arrest 1
- Symbol
- zar1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables mRNA binding activity and translation repressor activity. Acts upstream of with a negative effect on translation. Acts upstream of or within negative regulation of translation and positive regulation of oogenesis. Part of protein-containing complex. Is expressed in gonad; liver; oocyte stage I; and oocyte stage II. Orthologous to human ZAR1 (zygote arrest 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Miao et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ZAR1/RTP1-5-like, 3CxxC-type zinc finger | Zygote arrest protein 1 |
|---|---|---|---|---|
| UniProtKB:Q561Z6 | InterPro | 329 | ||
| UniProtKB:Q7T3T8 | InterPro | 329 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-90M5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109765 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173648 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194381 (1) | 1210 nt | ||
| Genomic | GenBank:BX537133 (2) | 249791 nt | ||
| Polypeptide | UniProtKB:Q561Z6 (1) | 329 aa |
- Jamieson-Lucy, A.H., Kobayashi, M., James Aykit, Y., Elkouby, Y., Escobar-Aguirre, M., Vejnar, C., Giraldez, A., Mullins, M.C. (2022) A proteomics approach identifies novel resident zebrafish Balbiani body proteins Cirbpa and Cirbpb. Developmental Biology. 484:1-11
- Hou, J., Liu, H., Wang, L., Duan, L., Li, S., Wang, X. (2018) Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio. Environmental science & technology. 52(14):7996-8004
- Miao, L., Yuan, Y., Cheng, F., Fang, J., Zhou, F., Ma, W., Jiang, Y., Huang, X., Wang, Y., Shan, L., Chen, D., Zhang, J. (2017) Translation repression by maternal RNA binding protein zar1 is essential for early oogenesis in zebrafish. Development (Cambridge, England). 144(1):128-138
- Wang, D., Xie, S.Y., Zhang, W., Sun, C.X., Huang, T., Wang, A.S., Han, X.L., Sun, G.R., Li, M. (2017) Cloning and expression analysis of zygote arrest 1 (Zar1) in New Zealand white rabbits. Journal of genetics. 96:3-8
- Nishimura, Y., Sasagawa, S., Ariyoshi, M., Ichikawa, S., Shimada, Y., Kawaguchi, K., Kawase, R., Yamamoto, R., Uehara, T., Yanai, T., Takata, R., Tanaka, T. (2015) Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. Frontiers in pharmacology. 6:199
- Heyn, P., Kircher, M., Dahl, A., Kelso, J., Tomancak, P., Kalinka, A.T., and Neugebauer, K.M. (2014) The earliest transcribed zygotic genes are short, newly evolved, and different across species. Cell Reports. 6(2):285-292
- Wang, Y., and Zhang, S. (2011) Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and "pre-hepatic" acute phase response. Functional & integrative genomics. 11(1):111-118
- Holth, T.F., Nourizadeh-Lillabadi, R., Blaesbjerg, M., Grung, M., Holbech, H., Petersen, G.I., Aleström, P., and Hylland, K. (2008) Differential gene expression and biomarkers in zebrafish (Danio rerio) following exposure to produced water components. Aquatic toxicology (Amsterdam, Netherlands). 90(4):277-291
- Cheng, W., Guo, L., Zhang, Z., Soo, H.M., Wen, C., Wu, W., and Peng, J. (2006) HNF factors form a network to regulate liver-enriched genes in zebrafish. Developmental Biology. 294(2):482-496
- Wardle, F.C., Odom, D.T., Bell, G.W., Yuan, B., Danford, T.W., Wiellette, E.L., Herbolsheimer, E., Sive, H.L., Young, R.A., and Smith, J.C. (2006) Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome biology. 7(8):R71
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