Gene

mapk1

ID
ZDB-GENE-030722-2
Name
mitogen-activated protein kinase 1
Symbol
mapk1 Nomenclature History
Previous Names
  • ERK2 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have MAP kinase activity. Involved in gastrulation. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including EVL; brain; cardiovascular system; retina; and superficial blastomere. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1).
Genome Resources
Note
None
Expression
All Expression Data
16 figures from 6 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mapk1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Noonan syndrome 13 Alliance Noonan syndrome 13 619087
Associated With mapk1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
Domain IPR000719 Protein kinase domain
Family IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Mitogen-activated protein (MAP) kinase, conserved site Mitogen-activated protein (MAP) kinase, ERK1/2 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q4VH14 369
UniProtKB:Q6P023 369
UniProtKB:F8W3M8 99
UniProtKB:Q7ZW72 369
UniProtKB:Q9DGR5 369
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-mapk monoclonal IgG1 Mouse
  • IHC
  • WB
Sigma-Aldrich
20
Ab3-mapk polyclonal IgG Rabbit
  • WB
Santa Cruz Biotechnology, Inc.
8
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations