ZFIN ID: ZDB-PUB-050907-3
Assembly of trigeminal sensory Ganglia by chemokine signaling
Knaut, H., Blader, P., Strähle, U., and Schier, A.F.
Date: 2005
Source: Neuron   47(5): 653-666 (Journal)
Registered Authors: Blader, Patrick, Knaut, Holger, Schier, Alexander, Strähle, Uwe
Keywords: none
MeSH Terms:
  • Animals
  • Cadherins/physiology
  • Chemokine CXCL12
  • Chemokines/physiology*
  • Chemokines, CXC/biosynthesis
  • Chemokines, CXC/genetics
  • Ganglia, Sensory/cytology
  • Ganglia, Sensory/physiology*
  • In Situ Hybridization
  • Morpholines/pharmacology
  • Neurons/physiology
  • Neurons, Afferent/physiology
  • Receptors, CXCR4/physiology
  • Signal Transduction/physiology*
  • Trigeminal Ganglion/cytology
  • Trigeminal Ganglion/physiology*
  • Zebrafish
PubMed: 16129396 Full text @ Neuron
Sensory neurons with related functions form ganglia, but how these precisely positioned clusters are assembled has been unclear. Here, we use the zebrafish trigeminal sensory ganglion as a model to address this question. We find that some trigeminal sensory neurons are born at the position where the ganglion is assembled, whereas others are born at a distance and have to migrate against opposing morphogenetic movements to reach the site of ganglion assembly. Loss of Cxcr4b-mediated chemokine signaling results in the formation of mispositioned ganglia. Conversely, ectopic sources of the chemokine SDF1a can attract sensory neurons. Transplantation experiments reveal that neuron-neuron interaction and the adhesion molecules E- and N-Cadherin also contribute to ganglion assembly. These results indicate that ganglion formation depends on the interplay of birthplace, chemokine attraction, cell-cell interaction, and cadherin-mediated adhesion.