ZFIN ID: ZDB-GENE-030715-1
Gene Name: fibroblast growth factor 10a
Gene Symbol: fgf10a    Nomenclature History

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Previous Names: fgf10, dae, daedalus, wu:fd11d03 (1), zgc:109774

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have fibroblast growth factor receptor binding activity and growth factor activity. Involved in several processes, including embryonic pectoral fin morphogenesis; posterior lateral line development; and regulation of hematopoietic stem cell differentiation. Predicted to localize to extracellular region. Is expressed in several structures, including ectoderm; fin bud; gut; head; and lateral line system. Human ortholog(s) of this gene implicated in LADD syndrome and aplasia of lacrimal and salivary glands. Orthologous to human FGF10 (fibroblast growth factor 10).
Genome Resources: Alliance (1),  Gene:359830 (1),  Ensembl(GRCz11):ENSDARG00000030932 (1)
GENE EXPRESSION
All Expression Data: 87 figures from 50 publications
Directly Submitted Expression Data: 6 figures (13 images) from Thisse et al., 2004 [MGC:109774]
  7 figures (19 images) from Thisse et al., 2005 [eu110]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 21-29 (21d-30d, 7.8mm, 10 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23903 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t24030 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tbvbo Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fgf10a N/A 4
    MO2-fgf10a N/A 1
    MO3-fgf10a N/A 5
    MO4-fgf10a N/A 2
    DISEASE ASSOCIATED WITH fgf10a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    aplasia of lacrimal and salivary glands Alliance Aplasia of lacrimal and salivary glands 180920
    LADD syndrome Alliance LADD syndrome 149730
    DISEASE ASSOCIATED WITH fgf10a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process liver development (more)
    Cellular Component extracellular region (more)
    Molecular Function fibroblast growth factor receptor binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fgf10a-201 (1)    Ensembl 2005
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fgf10a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(hsp70l:fgf10a) hsp70l fgf10a Danio rerio 1 1
    Tg(hsp70l:fgf10a-EGFP) hsp70l EGFPfgf10a Danio rerio 1 1
    tgbac(fgf10a:egfp-fgf10a,cryaa:dsred) cryaafgf10a DsRedEGFPfgf10a Danio rerio 1 1
    tgbac(fgf10a:sec-egfp,cryaa:dsred) cryaafgf10a DsRedEGFPSEC Danio rerio 1 1
    MARKER RELATIONSHIPS
    fgf10a Contained in: [BAC] CH211-262I10 (1)
    fgf10a Encodes: [EST] eu110 (1), fd11d03 (1)
    [cDNA] MGC:109774, MGC:192178 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_182870 (1) 2017 nt
    Genomic GenBank:BX927394 (1) 164899 nt
    Select Tool
    Polypeptide UniProtKB:Q4VBV7 (1) 201 aa
    Sequence Information (all 19)
    ORTHOLOGY for fgf10a ( Chr: 21 )
    CITATIONS (127)