Gene
stat1b
- ID
- ZDB-GENE-030616-23
- Name
- signal transducer and activator of transcription 1b
- Symbol
- stat1b Nomenclature History
- Previous Names
-
- si:by134g18.3
- si:by51f19.2
- si:dz199m19.2
- si:dz73o4.3
- si:dz87i4.1
- si:xx-51f19.2
- wu:fi49f02
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cardiovascular system; eye; intermediate cell mass of mesoderm; kidney; and lateral plate mesoderm. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1).
- Genome Resources
- Note
-
novel protein similar to human signal transduction and activator of transcription 1 (STAT1)
- Comparative Information
-
- All Expression Data
- 21 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Song et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-stat1b | Zhou et al., 2018 | |
| CRISPR2-stat1b | Zhou et al., 2018 | |
| MO1-stat1b | N/A | (2) |
| MO2-stat1b | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| chronic mucocutaneous candidiasis | Alliance | Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant | 614162 |
| immunodeficiency 31A | Alliance | Immunodeficiency 31A, mycobacteriosis, autosomal dominant | 614892 |
| immunodeficiency 31B | Alliance | Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive | 613796 |
| immunodeficiency 31C | Alliance | Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant | 614162 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR013799 | STAT transcription factor, protein interaction |
| Domain | IPR013800 | STAT transcription factor, all-alpha domain |
| Domain | IPR013801 | STAT transcription factor, DNA-binding |
| Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
| Family | IPR001217 | Transcription factor STAT |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012345 | STAT transcription factor, DNA-binding, N-terminal |
| Homologous_superfamily | IPR015988 | STAT transcription factor, coiled coil |
| Homologous_superfamily | IPR036535 | STAT transcription factor, N-terminal domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B5U5 | InterPro | 708 | |||||||||||
| UniProtKB:A0A8M9QF99 | InterPro | 634 | |||||||||||
| UniProtKB:A0A8M9PRY3 | InterPro | 609 | |||||||||||
| UniProtKB:A0A8M9Q4I2 | InterPro | 438 | |||||||||||
| UniProtKB:A0A8M9QAL7 | InterPro | 683 | |||||||||||
| UniProtKB:A0A8M9QJJ2 | InterPro | 640 | |||||||||||
| UniProtKB:B0S789 | InterPro | 725 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000001761 (1) | Havana | 682 nt | ||
| mRNA | ottdart00000001848 (1) | Havana | 1,706 nt | ||
| mRNA | ottdart00000056007 (1) | Havana | 1,527 nt | ||
| mRNA |
stat1b-201
(1)
|
Ensembl | 4,113 nt | ||
| mRNA |
stat1b-202
(1)
|
Ensembl | 535 nt | ||
| mRNA |
stat1b-204
(1)
|
Ensembl | 3,189 nt | ||
| ncRNA |
stat1b-003
(1)
|
Ensembl | 363 nt | ||
| ncRNA |
stat1b-004
(1)
|
Ensembl | 812 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(stat1b:lck-mScarletI,cryaa:mScarletI) |
|
| 1 | Denans et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196J1 | ZFIN Curated Data | |
| Contained in | BAC | IZAB-51F19 | ZFIN Curated Data | |
| Contained in | BAC | IZAB-85C7 | ZFIN Curated Data | |
| Contained in | BAC | XX-BY134G18 | ||
| Contained in | PAC | BUSM1-73O4 | ||
| Contained in | PAC | BUSM1-87I4 | ||
| Contained in | PAC | BUSM1-199M19 | ||
| Encodes | EST | fi49f02 | ||
| Encodes | cDNA | MGC:55503 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200091 (1) | 4113 nt | ||
| Genomic | GenBank:BX649377 (1) | 217898 nt | ||
| Polypeptide | UniProtKB:B0S789 (1) | 725 aa |
- Weiss, A., D'Amata, C., Pearson, B.J., Hayes, M.N. (2024) A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo. eLIFE. 13:
- Bernal-Berm�dez, B., Mart�nez-L�pez, A., Mart�nez-Morcillo, F.J., Tyrkalska, S.D., Mart�nez-Mench�n, T., Mesa-Del-Castillo, P., Cayuela, M.L., Mulero, V., Garc�a-Moreno, D. (2023) A zebrafish model of Ifih1-driven Aicardi-Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients. Frontiers in immunology. 14:12947661294766
- Withers, S.E., Rowlands, C.F., Tapia, V.S., Hedley, F., Mosneag, I.E., Crilly, S., Rice, G.I., Badrock, A.P., Hayes, A., Allan, S.M., Briggs, T.A., Kasher, P.R. (2023) Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome. Frontiers in immunology. 14:11009671100967
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
- Huang, W., Zhao, X., Ji, N., Guo, J., Feng, J., Chen, K., Wu, Y., Wang, J., Feng, H., Zou, J. (2022) IRF2 Cooperates with Phosphoprotein of Spring Viremia of Carp Virus to Suppress Antiviral Response in Zebrafish. Journal of virology. 96(22):e0131422
- Wang, Y.Y., Nie, L., Xu, X.X., Shao, T., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Essential Role of RIG-I in Hematopoietic Precursor Emergence in Primitive Hematopoiesis during Zebrafish Development. ImmunoHorizons. 6:283-298
- Seese, S.E., Deml, B., Muheisen, S., Sorokina, E., Semina, E.V. (2021) Genetic disruption of zebrafish mab21l1 reveals a conserved role in eye development and affected pathways. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(8):1056-1073
- Zang, L., Shimada, Y., Nakayama, H., Katsuzaki, H., Kim, Y., Chu, D.C., Juneja, L.R., Kuroyanagi, J., Nishimura, N. (2021) Preventive Effects of Green Tea Extract against Obesity Development in Zebrafish. Molecules. 26(9):
- Zhang, X.Y., Liu, Y.H., Liu, D.Z., Xu, J.Y., Zhang, Q. (2021) Insulin-Mimic Components in Acer truncatum Leaves: Bio-Guided Isolation, Annual Variance Profiling and Regulating Pathway Investigated by Omics. Pharmaceuticals (Basel, Switzerland). 14(7):
- Zhong, S., Li, H., Wang, Y.S., Wang, Y., Ji, G., Li, H.Y., Zhang, S., Liu, Z. (2021) Bmp8a is an essential positive regulator of antiviral immunity in zebrafish. Communications biology. 4:318
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