Gene
cacna1da
- ID
- ZDB-GENE-030616-135
- Name
- calcium channel, voltage-dependent, L type, alpha 1D subunit, a
- Symbol
- cacna1da Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable high voltage-gated calcium channel activity. Acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound; neuromuscular process controlling balance; and synapse organization. Located in basal plasma membrane and ribbon synapse. Is expressed in central nervous system; heart; and neuromast. Used to study schizophrenia. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la017886Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1422 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17298 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| tc323d | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tn004 | Allele with one point mutation | Unknown | Missense | ENU |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| schizophrenia | cacna1dasa17298/+ | standard conditions | Banono et al., 2020 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR014873 | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
| Domain | IPR031649 | Voltage-dependent L-type calcium channel, IQ-associated domain |
| Domain | IPR031688 | Voltage-gated calcium channel subunit alpha, C-terminal |
| Family | IPR002077 | Voltage-dependent calcium channel, alpha-1 subunit |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ion transport domain | Voltage-dependent calcium channel alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain | Voltage-dependent calcium channel, L-type, alpha-1 subunit | Voltage-dependent channel domain superfamily | Voltage-dependent L-type calcium channel, IQ-associated domain | Voltage-gated calcium channel subunit alpha, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q745 | InterPro | 2054 | ||||||||
| UniProtKB:A0A8M9QHK6 | InterPro | 2068 | ||||||||
| UniProtKB:A0A8M9QLJ7 | InterPro | 2082 | ||||||||
| UniProtKB:A0A8M9QD08 | InterPro | 2057 | ||||||||
| UniProtKB:A0A8M9QHK0 | InterPro | 2093 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cacna1da-201
(1)
|
Ensembl | 6,504 nt | ||
| mRNA |
cacna1da-202
(1)
|
Ensembl | 6,421 nt | ||
| mRNA |
cacna1fb-207
(1)
|
Ensembl | 6,662 nt | ||
| mRNA | ottdart00000001787 (1) | Havana | 2,432 nt | ||
| mRNA | ottdart00000001972 (1) | Havana | 4,125 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cacna1da | polyclonal | Rabbit |
|
10 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-243C14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-93P1 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-136D19 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-223C6 | ||
| Encodes | cDNA | MGC:194606 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_203484 (1) | 6526 nt | ||
| Genomic | GenBank:BX571969 (1) | 160905 nt | ||
| Polypeptide | UniProtKB:A0A8M9PUS4 (1) | 2093 aa |
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- McQuate, A., Knecht, S., Raible, D.W. (2023) Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells. eLIFE. 12:
- Shi, T., Beaulieu, M.O., Saunders, L.M., Fabian, P., Trapnell, C., Segil, N., Crump, J.G., Raible, D.W. (2023) Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. eLIFE. 12:
- Shrestha, A.P., Saravanakumar, A., Konadu, B., Madireddy, S., Gibert, Y., Vaithianathan, T. (2022) Embryonic Hyperglycemia Delays the Development of Retinal Synapses in a Zebrafish Model. International Journal of Molecular Sciences. 23(17)
- Venuto, A., Smith, C.P., Cameron-Pack, M., Erickson, T. (2022) Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2. Biology Open. 11(10):
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Zhang, Q., Kindt, K.S. (2022) Using Light-Sheet Microscopy to Study Spontaneous Activity in the Developing Lateral-Line System. Frontiers in cell and developmental biology. 10:819612
- Buchumenski, I., Holler, K., Appelbaum, L., Eisenberg, E., Junker, J.P., Levanon, E.Y. (2021) Systematic identification of A-to-I RNA editing in zebrafish development and adult organs. Nucleic acids research. 49(8):4325-4337
- Nam, Y.H., Rodriguez, I., Shin, S.W., Shim, J.H., Kim, N.W., Kim, M.C., Jeong, S.Y., Nuankaew, W., Hong, B.N., Kim, H., Kang, T.H. (2021) Characteristics of the New Insulin-Resistant Zebrafish Model. Pharmaceuticals (Basel, Switzerland). 14(7):
- Banono, N.S., Gawel, K., De Witte, L., Esguerra, C.V. (2020) Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours?. Molecular neurobiology. 58(2):877-894
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