Gene

timp2a

ID
ZDB-GENE-030612-1
Name
TIMP metallopeptidase inhibitor 2a
Symbol
timp2a Nomenclature History
Previous Names
  • timp2
  • TIMP2a (1)
  • etID32613.12 (1)
  • fa96h09
  • wu:fa96h09 (1)
  • zgc:136726
Type
protein_coding_gene
Location
Ambiguous Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of proteolysis; response to cytokine; and response to hormone. Localizes to extracellular space. Is expressed in several structures, including brain; heart; liver; post-vent region; and trunk. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Zhang et al., 2003
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With timp2a Human Ortholog
No data available
Associated With timp2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030490 Tissue inhibitor of metalloproteinase, conserved site
Domain IPR001134 Netrin domain
Family IPR001820 Protease inhibitor I35 (TIMP)
Family IPR015613 Metalloproteinase inhibitor 2
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR027465 Proteinase inhibitor I35b (TIMP), C-terminal
Domain Details Per Protein
Protein Length Metalloproteinase inhibitor 2 Netrin domain Protease inhibitor I35 (TIMP) Proteinase inhibitor I35b (TIMP), C-terminal Tissue inhibitor of metalloproteinase, conserved site Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:Q1MTE8 220
UniProtKB:Q1RLX2 220
UniProtKB:Q7SZM6 220
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations