ZFIN ID: ZDB-GENE-030605-1
Gene Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a
Gene Symbol: smarca4a    Nomenclature History

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Previous Names: brg1 (2), smarca2, smarca4, brahma-related gene 1 (1), wu:fb51a08, yng, young

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have DNA binding activity; DNA-dependent ATPase activity; and transcription factor binding activity. Involved in several processes, including animal organ development; fin regeneration; and nervous system development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; lung non-small cell carcinoma; and rhabdoid cancer. Is expressed in head; mesoderm; nervous system; pectoral fin; and presumptive neural retina. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4).
Genome Resources: Alliance (1),  Gene:353295 (1),  Ensembl(GRCz11):ENSDARG00000077226 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a8 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • a50 Point Mutation Unknown Unknown ENU
    s481 Point Mutation Unknown Premature Stop ENU
    sa12514 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19981 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-smarca4a N/A 5
    MO2-smarca4a N/A 1
    MO3-smarca4a N/A 1
    DISEASE ASSOCIATED WITH smarca4a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Coffin-Siris syndrome 4 Alliance Coffin-Siris syndrome 4 614609
    {Rhabdoid tumor predisposition syndrome 2} 613325
    DISEASE ASSOCIATED WITH smarca4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process activation of MAPKKK activity (more)
    Cellular Component nucleus (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000330 SNF2-related, N-terminal domain
    Domain IPR001487 Bromodomain
    Domain IPR001650 Helicase, C-terminal
    Domain IPR006576 BRK domain
    Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
    Domain IPR014012 Helicase/SANT-associated domain
    Domain IPR014978 Glutamine-Leucine-Glutamine, QLQ
    Conserved_site IPR018359 Bromodomain, conserved site
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Domain IPR029295 Snf2, ATP coupling domain
    Family IPR030100 SWI/SNF complex subunit BRG1
    Homologous_superfamily IPR036427 Bromodomain-like superfamily
    Homologous_superfamily IPR037259 BRK domain superfamily
    Homologous_superfamily IPR038718 SNF2-like, N-terminal domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smarca4a-201 (1)    Ensembl 5680
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smarca4a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(ubb:LOXP-DsRed-LOXP-smarca4a) ubb DsRedLOXPsmarca4a Danio rerio 1 1
    MARKER RELATIONSHIPS
    smarca4a Contained in: [BAC] CH211-224D23 (1)
    smarca4a Contains: [SNP] rs3727693 (1)
    smarca4a Encodes: [EST] ay205256 (2), fb51a08, IMAGE:5611934 (1), IMAGE:6909706 (1), IMAGE:7138284 (1)
    [cDNA] MGC:77219 (1), MGC:195345 (1), MGC:195348 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_181603 (1) 4884 bp
    Genomic GenBank:BX322663 (1) 145520 bp
    Select Tool
    Polypeptide UniProtKB:Q7ZSY3 (1) 1627 aa
    Sequence Information (all 33)
    ORTHOLOGY for smarca4a ( Chr: 3 )
    CITATIONS (47)