Gene

smarca4a

ID
ZDB-GENE-030605-1
Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a
Symbol
smarca4a Nomenclature History
Previous Names
  • brg1 (2)
  • smarca2
  • smarca4
  • brahma-related gene 1 (1)
  • wu:fb51a08
  • yng
  • young
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have DNA binding activity; DNA-dependent ATPase activity; and transcription factor binding activity. Involved in several processes, including animal organ development; fin regeneration; and nervous system development. Predicted to localize to nucleus. Is expressed in head; mesoderm; nervous system; pectoral fin; and presumptive neural retina. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; lung non-small cell carcinoma; and rhabdoid cancer. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4).
Genome Resources
Note
None
Expression
All Expression Data
17 figures from 7 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
20 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smarca4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Coffin-Siris syndrome 4 Alliance Coffin-Siris syndrome 4 614609
{Rhabdoid tumor predisposition syndrome 2} 613325
Associated With smarca4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018359 Bromodomain, conserved site
Domain IPR001487 Bromodomain
Domain IPR001650 Helicase, C-terminal
Domain IPR006576 BRK domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR014012 Helicase/SANT-associated domain
Domain IPR014978 Glutamine-Leucine-Glutamine, QLQ
Domain IPR029295 Snf2, ATP coupling domain
Family IPR030100 SWI/SNF complex subunit BRG1
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036427 Bromodomain-like superfamily
Homologous_superfamily IPR037259 BRK domain superfamily
Homologous_superfamily IPR038718 SNF2-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length BRK domain BRK domain superfamily Bromodomain Bromodomain, conserved site Bromodomain-like superfamily Glutamine-Leucine-Glutamine, QLQ Helicase, C-terminal Helicase/SANT-associated domain Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase Snf2, ATP coupling domain SNF2-like, N-terminal domain superfamily SWI/SNF complex subunit BRG1
UniProtKB:Q803N3 562
UniProtKB:Q7ZSY3 1627
UniProtKB:Q6NZ27 193
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations