Gene

smarca4a

ID
ZDB-GENE-030605-1
Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4a
Symbol
smarca4a Nomenclature History
Previous Names
  • brg1 (2)
  • smarca2
  • smarca4
  • brahma-related gene 1 (1)
  • wu:fb51a08
  • yng
  • young
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have DNA binding activity; DNA-dependent ATPase activity; and transcription factor binding activity. Involved in several processes, including animal organ development; fin regeneration; and nervous system development. Predicted to localize to nucleus. Is expressed in head; mesoderm; nervous system; pectoral fin; and presumptive neural retina. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; lung non-small cell carcinoma; and rhabdoid cancer. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
20 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smarca4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Coffin-Siris syndrome 4 Alliance Coffin-Siris syndrome 4 614609
{Rhabdoid tumor predisposition syndrome 2} 613325
Associated With smarca4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018359 Bromodomain, conserved site
Domain IPR000330 SNF2-related domain
Domain IPR001487 Bromodomain
Domain IPR001650 Helicase, C-terminal
Domain IPR006576 BRK domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR014012 Helicase/SANT-associated domain
Domain IPR014978 Glutamine-Leucine-Glutamine, QLQ
Domain IPR029295 Snf2, ATP coupling domain
Family IPR030100 SWI/SNF complex subunit BRG1
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036427 Bromodomain-like superfamily
Homologous_superfamily IPR037259 BRK domain superfamily
Homologous_superfamily IPR038718 SNF2-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length BRK domain BRK domain superfamily Bromodomain Bromodomain, conserved site Bromodomain-like superfamily Glutamine-Leucine-Glutamine, QLQ Helicase, C-terminal Helicase/SANT-associated domain Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase Snf2, ATP coupling domain SNF2-like, N-terminal domain superfamily SNF2-related domain SWI/SNF complex subunit BRG1
UniProtKB:Q7ZSY3 1627
UniProtKB:Q803N3 562
UniProtKB:Q6NZ27 193
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations