Gene
tnnt3b
- ID
- ZDB-GENE-030520-2
- Name
- troponin T type 3b (skeletal, fast)
- Symbol
- tnnt3b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable tropomyosin binding activity; troponin C binding activity; and troponin I binding activity. Acts upstream of or within sarcomere organization. Predicted to be part of troponin complex. Is expressed in musculature system and somite. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B and distal arthrogryposis type 2B2. Orthologous to human TNNT3 (troponin T3, fast skeletal type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb44 (4 images)
- IMAGE:7145902 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ferrante et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa21032 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal arthrogryposis type 2B2 | Alliance | Arthrogryposis, distal, type 2B2 | 618435 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Troponin | Troponin domain superfamily | Troponin T |
|---|---|---|---|---|---|
| UniProtKB:F1Q5F2 | InterPro | ||||
| UniProtKB:A8WGA6 | InterPro | 284 | |||
| UniProtKB:Q7ZZW4 | InterPro | 232 | |||
| UniProtKB:A0AB13A9B5 | InterPro | 238 | |||
| UniProtKB:A0AB13AA21 | InterPro | 232 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnnt3b-201
(1)
|
Ensembl | 855 nt | ||
| mRNA |
tnnt3b-202
(1)
|
Ensembl | 687 nt | ||
| mRNA |
tnnt3b-203
(1)
|
Ensembl | 1,050 nt | ||
| mRNA |
tnnt3b-204
(1)
|
Ensembl | 1,068 nt | ||
| mRNA |
tnnt3b-206
(1)
|
Ensembl | 1,061 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-223L2 | ZFIN Curated Data | |
| Encodes | EST | cb44 | (2) | |
| Encodes | EST | IMAGE:7145902 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:77790 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:172289 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198355 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110416 (1) | 1254 nt | ||
| Genomic | GenBank:BX842701 (1) | 172765 nt | ||
| Polypeptide | UniProtKB:A0AB32TUE0 (1) | 297 aa |
- Mao, K., Li, X., Chen, Z., Dong, X., Zhangsun, D., Zhu, X., Luo, S. (2022) α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Frontiers in pharmacology. 13:802917
- Li, F., Long, Y., Xie, J., Ren, J., Zhou, T., Song, G., Li, Q., Cui, Z. (2021) Generation of GCaMP6s-Expressing Zebrafish to Monitor Spatiotemporal Dynamics of Calcium Signaling Elicited by Heat Stress. International Journal of Molecular Sciences. 22(11):
- Ranjani, T.S., Pitchika, G.K., Yedukondalu, K., Gunavathi, Y., Daveedu, T., Sainath, S.B., Philip, G.H., Pradeepkiran, J.A. (2020) Phenotypic and transcriptomic changes in zebrafish (Danio rerio) embryos/larvae following cypermethrin exposure. Chemosphere. 249:126148
- Viana, J., Wildman, N., Hannon, E., Farbos, A., Neill, P.O., Moore, K., van Aerle, R., Paull, G., Santos, E., Mill, J. (2020) Clozapine-induced transcriptional changes in the zebrafish brain. NPJ schizophrenia. 6:3
- Zhou, Z., Zheng, L., Tang, C., Chen, Z., Zhu, R., Peng, X., Wu, X., Zhu, P. (2020) Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Frontiers in Physiology. 11:565307
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Kwon, O.K., Kim, S.J., Lee, S. (2018) First profiling of lysine crotonylation of myofilament proteins and ribosomal proteins in zebrafish embryos. Scientific Reports. 8:3652
- Gomes, R.S., Skroblin, P., Munster, A.B., Tomlins, H., Langley, S.R., Zampetaki, A., Yin, X., Wardle, F., Mayr, M. (2016) "Young at heart": Regenerative potential linked to immature cardiac phenotypes. Journal of Molecular and Cellular Cardiology. 92:105-8
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Long, Y., Yan, J., Song, G., Li, X., Li, X., Li, Q., Cui, Z. (2015) Transcriptional events co-regulated by hypoxia and cold stresses in Zebrafish larvae. BMC Genomics. 16:385
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