Gene

tnnt2c

ID
ZDB-GENE-030520-1
Name
troponin T2c, cardiac
Symbol
tnnt2c Nomenclature History
Previous Names
  • tnnt1
  • cb328 (1)
  • sb:cb328
  • zgc:86847
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have tropomyosin binding activity; troponin C binding activity; and troponin I binding activity. Involved in sarcomere organization. Predicted to localize to troponin complex. Is expressed in mesoderm; musculature system; somite; and trunk mesenchyme. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type).
Genome Resources
Note
None
Expression
All Expression Data
26 figures from 7 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Ferrante et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnnt2c Human Ortholog
No data available
Associated With tnnt2c Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001978 Troponin
Family IPR027707 Troponin T
Homologous_superfamily IPR038077 Troponin domain superfamily
Domain Details Per Protein
Protein Length Troponin Troponin domain superfamily Troponin T
UniProtKB:Q8AVB1 290
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Orthology Note
Hsiao, et al. 2003 (ZDB-PUB-030516-1) reported orthology to human TNNT1 and mouse Tnnt1 based on amino acid similarity. Subsequent analysis suggests tnnt1 (ZDB-GENE-080723-27) is the zebrafish ortholog based on amino acid similarity and conserved location.
Citations