Gene
tnnt2c
- ID
- ZDB-GENE-030520-1
- Name
- troponin T2c, cardiac
- Symbol
- tnnt2c Nomenclature History
- Previous Names
-
- tnnt1
- cb328 (1)
- sb:cb328
- zgc:86847
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable tropomyosin binding activity; troponin C binding activity; and troponin I binding activity. Acts upstream of or within sarcomere organization. Predicted to be part of troponin complex. Is expressed in mesoderm; musculature system; somite; and trunk mesenchyme. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb328 (10 images)
- eu913 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Ferrante et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa224 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Troponin | Troponin domain superfamily | Troponin T |
|---|---|---|---|---|---|
| UniProtKB:Q8AVB1 | InterPro | 290 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnnt2c-201
(1)
|
Ensembl | 1,909 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-222F8 | ZFIN Curated Data | |
| Encodes | EST | cb328 | ZFIN Curated Data | |
| Encodes | EST | cegs953 | Rauch et al., 2003 | |
| Encodes | EST | eu913 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:86847 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181499 (1) | 1917 nt | ||
| Genomic | GenBank:BX005210 (1) | 207949 nt | ||
| Polypeptide | UniProtKB:Q8AVB1 (1) | 290 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Hsiao, et al. 2003 (ZDB-PUB-030516-1) reported orthology to human TNNT1 and mouse Tnnt1 based on amino acid similarity. Subsequent analysis suggests tnnt1 (ZDB-GENE-080723-27) is the zebrafish ortholog based on amino acid similarity and conserved location.
No data available
- Hofeichner, J., Gahr, B.M., Huber, M., Boos, A., Rottbauer, W., Just, S. (2023) CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo. Scientific Reports. 13:2267922679
- Singh Angom, R., Wang, Y., Wang, E., Dutta, S., Mukhopadhyay, D. (2023) Conditional, Tissue-Specific CRISPR/Cas9 Vector System in Zebrafish Reveals the Role of Nrp1b in Heart Regeneration. Arteriosclerosis, Thrombosis, and Vascular Biology. 43(10):1921-1934
- Zhou, C., Zhao, W., Zhang, S., Ma, J., Sultan, Y., Li, X. (2022) High-throughput transcriptome sequencing reveals the key stages of cardiovascular development in zebrafish embryos. BMC Genomics. 23:587
- Sharma, D., Sehgal, P., Mathew, S., Vellarikkal, S.K., Singh, A.R., Kapoor, S., Jayarajan, R., Scaria, V., Sivasubbu, S. (2019) A genome-wide map of circular RNAs in adult zebrafish. Scientific Reports. 9:3432
- Zou, X., Liu, Q., Guo, S., Zhu, J., Han, J., Xia, Z., Du, Y., Wei, L., Shang, J. (2019) A Novel Zebrafish Larvae Hypoxia/Reoxygenation Model for Assessing Myocardial Ischemia/Reperfusion Injury. Zebrafish. 16(5):434-442
- Nagata, Y., Yamagishi, M., Konno, T., Nakanishi, C., Asano, Y., Ito, S., Nakajima, Y., Seguchi, O., Fujino, N., Kawashiri, M.A., Takashima, S., Kitakaze, M., Hayashi, K. (2017) Heat Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy. Scientific Reports. 7:17417
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Haug, M.F., Gesemann, M., Lazovic, V., Neuhauss, S.C. (2015) Eumetazoan Cryptochrome Phylogeny and Evolution. Genome biology and evolution. 7(2):601-19
- Shih, Y.H., Zhang, Y., Ding, Y., Ross, C.A., Li, H., Olson, T.M., Xu, X. (2015) Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish. Circulation. Cardiovascular genetics. 8(2):261-9
- Beasley, A., Graham, C., Otter, R., and Elrod-Erickson, M. (2014) A molecular method for assessing the effects of potential contaminants on the rate of zebrafish (Danio rerio) development. Environmental toxicology and chemistry. 33(1):238-42
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