Gene
chrm2a
- ID
- ZDB-GENE-030314-1
- Name
- cholinergic receptor, muscarinic 2a
- Symbol
- chrm2a Nomenclature History
- Previous Names
-
- chrm2
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables G protein-coupled acetylcholine receptor activity. Acts upstream of or within cardiac conduction system development and negative regulation of heart rate. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Is expressed in several structures, including cardiovascular system; central nervous system; digestive system; head; and neural tube. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu64 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Muscarinic acetylcholine receptor family | Muscarinic acetylcholine receptor M2 |
|---|---|---|---|---|---|
|
UniProtKB:B3DKN8
|
495 | ||||
|
UniProtKB:Q801M4
|
495 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
chrm2a-201
(1)
|
Ensembl | 1,754 nt | ||
| mRNA |
chrm2a-202
(1)
|
Ensembl | 1,605 nt |
Interactions and Pathways
No data available
Plasmids
No data available