Gene
mych
- ID
- ZDB-GENE-030219-51
- Name
- myelocytomatosis oncogene homolog
- Symbol
- mych Nomenclature History
- Previous Names
-
- id:ibd5144
- V-Myc3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within neural crest cell development. Located in nucleus. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural keel; and pharyngeal arch.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Hong et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mych | N/A | Hong et al., 2008 |
| MO2-mych | N/A | Hong et al., 2008 |
| MO3-mych | N/A | Kotkamp et al., 2014 |
| MO4-mych | N/A | Kotkamp et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Leucine zipper, Myc | Myc family transcription factors | Myc-type, basic helix-loop-helix (bHLH) domain | Transcription regulator Myc | Transcription regulator Myc, N-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B2KUA9 | InterPro | 360 | ||||||
| UniProtKB:A0AB32TV28 | InterPro | 360 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-231H5 | ZFIN Curated Data | |
| Encodes | EST | ibd5144 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126109 (1) | 1975 nt | ||
| Genomic | GenBank:BX649289 (1) | 124708 nt | ||
| Polypeptide | UniProtKB:A0AB32TV28 (1) | 360 aa |
No data available
- Grabinski, S.E., Parsana, D., Perkins, B.D. (2023) Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways. Frontiers in molecular neuroscience. 16:11488401148840
- Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119
- Hasanpour, S., Eagderi, S., Poorbagher, H., Angrand, P.O., Hasanpour, M., Lashkarbolok, M. (2021) The effect of Activin pathway modulation on the expression of both pluripotency and differentiation markers during early zebrafish development compared with other vertebrates. Journal of experimental zoology. Part B, Molecular and developmental evolution. 336(7):562-575
- Pradhan, S.J., Reddy, P.C., Smutny, M., Sharma, A., Sako, K., Oak, M.S., Shah, R., Pal, M., Deshpande, O., Dsilva, G., Tang, Y., Mishra, R., Deshpande, G., Giraldez, A.J., Sonawane, M., Heisenberg, C.P., Galande, S. (2021) Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nature communications. 12:6094
- Sahu, A., Devi, S., Jui, J., Goldman, D. (2021) Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury. Glia. 69(12):2882-2898
- Tingle, C.F., Magnuson, B., Zhao, Y., Heisel, C.J., Kish, P.E., Kahana, A. (2019) Paradoxical Changes Underscore Epigenetic Reprogramming During Adult Zebrafish Extraocular Muscle Regeneration. Investigative ophthalmology & visual science. 60:4991-4999
- Elsaeidi, F., Macpherson, P., Mills, E.A., Jui, J., Flannery, J.G., Goldman, D. (2018) Notch suppression collaborates with Ascl1 and Lin28 to unleash a regenerative response in fish retina, but not in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(9):2246-2261
- Cal, L., MegÍas, M., Cerdá-Reverter, J.M., Postlethwait, J.H., Braasch, I., Rotllant, J. (2017) BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish. Journal of experimental zoology. Part B, Molecular and developmental evolution. 328(7):697-708
- Chakraborty, A., Uechi, T., Nakajima, Y., Gazda, H.T., O'Donohue, M.F., Gleizes, P.E., Kenmochi, N. (2017) Cross talk between TP53 and c-Myc in the pathophysiology of Diamond-Blackfan anemia: Evidence from RPL11-deficient in vivo and in vitro models. Biochemical and Biophysical Research Communications. 495(2):1839-1845
- Choi, T.Y., Khaliq, M., Tsurusaki, S., Ninov, N., Stainier, D.Y.R., Tanaka, M., Shin, D. (2017) Bmp Signaling Governs Biliary-Driven Liver Regeneration in Zebrafish via Tbx2b and Id2a. Hepatology (Baltimore, Md.). 66(5):1616-1630
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