Gene
dact2
- ID
- ZDB-GENE-030131-9975
- Name
- dishevelled-binding antagonist of beta-catenin 2
- Symbol
- dact2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Involved in negative regulation of nodal signaling pathway. Acts upstream of or within Wnt signaling pathway and mesoderm morphogenesis. Predicted to be located in late endosome; nucleus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including blastodisc; brain; digestive system; germ ring; and mesoderm. Used to study bile duct carcinoma; pancreatic carcinoma; and retinitis pigmentosa. Orthologous to human DACT2 (dishevelled binding antagonist of beta catenin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018643Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35579 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| yu31 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dact2 | Kim et al., 2020 | |
| MO1-dact2 | N/A | (3) |
| MO2-dact2 | N/A | Waxman et al., 2004 |
| MO3-dact2 | N/A | (2) |
| MO4-dact2 | N/A | (2) |
| MO5-dact2 | N/A | Yi et al., 2020 |
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Human Disease
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR024843 | Dapper |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Dapper |
|---|---|---|---|
| UniProtKB:F1RE13 | InterPro | 837 | |
| UniProtKB:Q673G8 | InterPro | 837 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-14A4 | ZFIN Curated Data | |
| Encodes | EST | fe24f12 | ZFIN Curated Data | |
| Encodes | EST | tdsubc_1d9 | ||
| Encodes | cDNA | MGC:109729 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152832 | ZFIN Curated Data | |
| Is Hybridized by | EST | fj81h03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077794 (1) | 3064 nt | ||
| Genomic | GenBank:CT573408 (2) | 155684 nt | ||
| Polypeptide | UniProtKB:F1RE13 (1) | 837 aa |
- Carroll, S.H., Schafer, S., Kawasaki, K., Tsimbal, C., Jule, A.M., Hallett, S.A., Li, E., Liao, E.C. (2024) Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis. eLIFE. 13:
- Carroll, S.H., Macias Trevino, C., Li, E.B., Kawasaki, K., Myers, N., Hallett, S.A., Alhazmi, N., Cotney, J., Carstens, R.P., Liao, E.C. (2020) An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development (Cambridge, England). 147(24):
- Kim, D.H., Kim, E.J., Kim, D.H., Park, S.W. (2020) Dact2 is involved in the regulation of epithelial-mesenchymal transition. Biochemical and Biophysical Research Communications. 524(1):190-197
- Yi, Z., Ouyang, J., Sun, W., Li, S., Xiao, X., Zhang, Q. (2020) Comparative exome sequencing reveals novel candidate genes for retinitis pigmentosa. EBioMedicine. 56:102792
- Ribas, L., Vanezis, K., Imués, M.A., Piferrer, F. (2017) Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads. Epigenetics & chromatin. 10:59
- Shi, W.J., Zhao, J.L., Jiang, Y.X., Huang, G.Y., Liu, Y.S., Zhang, J.N., Ying, G.G. (2017) TRANSCRIPTIONAL AND HISTOLOGICAL ALTERATIONS IN GONAD OF ADULT ZEBRAFISH AFTER EXPOSURE TO THE SYNTHETIC PROGESTIN NORGESTREL. Environmental toxicology and chemistry. 36(12):3267-3276
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Mandal, A., Waxman, J. (2014) Retinoic acid negatively regulates dact3b expression in the hindbrain of zebrafish embryos. Gene expression patterns : GEP. 16(2):122-9
- Fodor, E., Zsigmond, A., Horváth, B., Molnár, J., Nagy, I., Tóth, G., Wilson, S.W., and Varga, M. (2013) Full transcriptome analysis of early dorsoventral patterning in zebrafish. PLoS One. 8(7):e70053
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