PUBLICATION

Two Frodo/Dapper homologs are expressed in the developing brain and mesoderm of zebrafish

Authors

Gillhouse, M., Wagner Nyholm, M., Hikasa, H., Sokol, S.Y., and Grinblat, Y.

ID

ZDB-PUB-040611-4

Date

2004

Source

Developmental Dynamics : an official publication of the American Association of Anatomists 230(3): 403-409 (Journal)

Registered Authors

Grinblat, Yevgenya

Keywords

Frodo, Dapper, wnt signaling, neural plate, diencephalon, notochord, paraxial mesoderm, intermediate mesoderm, lateral mesoderm

MeSH Terms

Animals
Brain/metabolism*
Carrier Proteins
Xenopus Proteins
Sequence Homology, Amino Acid
Adaptor Proteins, Signal Transducing
Open Reading Frames
Mesoderm/metabolism*
Protein Structure, Tertiary
Zebrafish Proteins/chemistry
Zebrafish Proteins/genetics*
Zebrafish Proteins/metabolism*
Evolution, Molecular
Amino Acid Sequence
Zebrafish/embryology*
Molecular Sequence Data
Embryo, Nonmammalian

(all 17)

PubMed

15188426 Full text @ Dev. Dyn.

Abstract

Members of the Wnt family of extracellular proteins play essential roles during many phases of vertebrate embryonic development. The molecular mechanism of their action involves a complex cascade of intracellular signaling events, which remains to be understood completely. Recently, two novel cytoplasmic modulators of Wnt signaling, Frodo and Dapper, were identified in Xenopus. We report isolation of their homologs in zebrafish, and show that these genes, frd1 and frd2, are expressed in restricted domains during embryogenesis. Both genes are expressed during early gastrulation in the future mesendoderm, and continue to be expressed in distinct patterns in the forming neurectoderm and mesoderm. Comparative sequence analysis and similar expression patterns argue that frd1 is the zebrafish ortholog of Frodo and Dapper, whereas frd2 is a more divergent member of the same family. Our data suggest important roles for zebrafish frd1 and frd2 in patterning the neural plate and several mesodermal derivatives. Developmental Dynamics 230:403-409, 2004. Copyright 2004 Wiley-Liss, Inc.

Genes / Markers

Figures

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Expression

Gene	Fish	Conditions	Stage	Anatomy	Assay	Figure
dact1	WT	standard conditions	75%-epiboly	axial mesoderm	ISH	Fig. 2
dact1	WT	standard conditions	5-9 somites	head mesenchyme	ISH	Fig. 2
dact1	WT	standard conditions	Prim-5	hypothalamus	ISH	Fig. 2
dact1	WT	standard conditions	10-13 somites	lateral plate mesoderm	ISH	Fig. 2
dact1	WT	standard conditions	Shield	margin	ISH	Fig. 2
dact1	WT	standard conditions	Bud	neural plate	ISH	Fig. 2
dact1	WT	standard conditions	5-9 somites	neural plate	ISH	Fig. 2
dact1	WT	standard conditions	75%-epiboly	neuroectoderm	ISH	Fig. 2
dact1	WT	standard conditions	10-13 somites	optic vesicle	ISH	Fig. 2
dact1	WT	standard conditions	10-13 somites	paraxial mesoderm	ISH	Fig. 2

1 - 10 of 30

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Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Fish
WT

Antibodies

Orthology

Gene	Orthology
dact2

Engineered Foreign Genes

Mapping

Gillhouse et al., 2004 ZDB-PUB-040611-4 PMID:15188426

Two Frodo/Dapper homologs are expressed in the developing brain and mesoderm of zebrafish

Gillhouse et al., 2004

ZDB-PUB-040611-4
PMID:15188426