Gene

rad21a

ID
ZDB-GENE-030131-994
Name
RAD21 cohesin complex component a
Symbol
rad21a Nomenclature History
Previous Names
  • rad21
  • wu:fb55d02
  • wu:fb93f04
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in several processes, including chordate embryonic development; enteric nervous system development; and heart development. Predicted to localize to meiotic cohesin complex and nuclear cohesin complex. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4. Is expressed in several structures, including brain; digestive system; head; optic cup; and ventricular zone. Orthologous to human RAD21 (RAD21 cohesin complex component).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
33 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rad21a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cornelia de Lange syndrome 4 Alliance Cornelia de Lange syndrome 4 614701
?Mungan syndrome 611376
Associated With rad21a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006909 Rad21/Rec8-like protein, C-terminal, eukaryotic
Domain IPR006910 Rad21/Rec8-like protein, N-terminal
Family IPR039781 Rad21/Rec8-like protein
Homologous_superfamily IPR023093 ScpA-like, C-terminal
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Rad21/Rec8-like protein Rad21/Rec8-like protein, C-terminal, eukaryotic Rad21/Rec8-like protein, N-terminal ScpA-like, C-terminal Winged helix DNA-binding domain superfamily
UniProtKB:Q6TEL1 643
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-rad21 polyclonal Rabbit
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations