Gene

hells

ID
ZDB-GENE-030131-9923
Name
helicase, lymphoid specific
Symbol
hells Nomenclature History
Previous Names
  • cb65 (1)
  • im:6911667
  • sb:cb65
  • sb:cb749
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have DNA binding activity and DNA-dependent ATPase activity. Involved in regulation of DNA methylation. Predicted to localize to nucleus. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; margin; and pectoral fin musculature. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Dunican et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hells Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency-centromeric instability-facial anomalies syndrome 4 Alliance Immunodeficiency-centromeric instability-facial anomalies syndrome 4 616911
Associated With hells Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000330 SNF2-related domain
Domain IPR001650 Helicase, C-terminal
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR038718 SNF2-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase SNF2-like, N-terminal domain superfamily SNF2-related domain
UniProtKB:Q3BDS6 853
UniProtKB:Q5BLD7 252
UniProtKB:A0A2R8Q4P5 838
UniProtKB:B7ZD98 853
UniProtKB:Q08CT9 769
UniProtKB:A4FVH1 270
UniProtKB:A8WFW2 290
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations