Gene

yap1

ID

ZDB-GENE-030131-9710

Name

Yes1 associated transcriptional regulator

Symbol

yap1 Nomenclature History

Previous Names

yap (1)
cb194 (1)
sb:cb194
si:ch211-181p1.5 (1)
si:dkey-3b8.3
wu:fc18c04
zgc:158380

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Involved in several processes, including animal organ development; fin regeneration; and regulation of gene expression. Localizes to chromatin and nucleus. Used to study coloboma. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Is expressed in several structures, including central nervous system; digestive system; ectoderm; fin; and mesoderm. Orthologous to human YAP1 (Yes1 associated transcriptional regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

30 figures from 19 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb194 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 50 figures from 21 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With yap1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
uveal coloboma-cleft lip and palate-intellectual disability	Alliance	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	120433

Associated With yap1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
coloboma	yap1^nl13/nl13	standard conditions	Miesfeld et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR053819	TEAD interating region 3, omega loop
Domain	IPR001202	WW domain
Family	IPR051583	Yes-associated protein 1
Homologous_superfamily	IPR036020	WW domain superfamily