Gene
ogt.1
- ID
- ZDB-GENE-030131-9631
- Name
- O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1
- Symbol
- ogt.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables protein N-acetylglucosaminyltransferase activity. Acts upstream of or within protein O-linked glycosylation. Is expressed in brain; caudal fin; and trunk. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Webster et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ogt.1 | (2) | |
| CRISPR2-ogt.1 | (2) | |
| MO1-ogt.1 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| non-syndromic X-linked intellectual disability 106 | Alliance | Intellectual developmental disorder, X-linked 106 | 300997 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR029489 | O-GlcNAc transferase, C-terminal |
| Family | IPR037919 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Repeat | IPR019734 | Tetratricopeptide repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | O-GlcNAc transferase, C-terminal | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IVJ0 | InterPro | 1102 | ||||
| UniProtKB:A0A8M3B8G4 | InterPro | 886 | ||||
| UniProtKB:Q5GA11 | InterPro | 1046 | ||||
| UniProtKB:Q5GA12 | InterPro | 1052 | ||||
| UniProtKB:Q5GA13 | InterPro | 1062 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-102M7 | ZFIN Curated Data | |
| Encodes | EST | fc12b01 | ZFIN Curated Data | |
| Encodes | EST | fm81g08 | ||
| Encodes | cDNA | MGC:162075 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195351 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017359 (1) | 3189 nt | ||
| Genomic | GenBank:BX323828 (1) | 206011 nt | ||
| Polypeptide | UniProtKB:A0A0R4IVJ0 (1) | 1102 aa |
- Matheny-Rabun, C., Mokashi, S.S., Radenkovic, S., Wiggins, K., Dukes-Rimsky, L., Angel, P., Ghesquiere, B., Kozicz, T., Steet, R., Morava, E., Flanagan-Steet, H. (2024) O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder. Cell Reports. 43:114976114976
- Park, J., Kim, D.Y., Hwang, G.S., Han, I.O. (2023) Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish. Journal of neuroinflammation. 20:257257
- Lee, Y., Park, J., Kim, S.M., Nam, K., Lee, W., Cho, H., Han, I.O. (2020) Sleep deprivation impairs learning and memory by decreasing protein O-GlcNAcylation in the brain of adult zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:853-864
- DeRossi, C., Shtraizent, N., Nayar, S., Sachidanandam, R., Katz, L.S., Prince, A., Koh, A.P., Vincek, A., Hadas, Y., Hoshida, Y., Scott, D.K., Eliyahu, E., Freeze, H.H., Sadler, K.C., Chu, J. (2017) MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect. eLIFE. 6
- Varshney, G.K., Pei, W., LaFave, M.C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S.C., Prakash, A., Chen, W., Sood, R., Ledin, J., Burgess, S.M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome research. 25(7):1030-42
- Rissone, A., Sangiorgio, L., Monopoli, M., Beltrame, M., Zucchi, I., Bussolino, F., Arese, M., and Cotelli, F. (2010) Characterization of the neuroligin gene family expression and evolution in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(2):688-702
- Webster, D.M., Teo, C.F., Sun, Y., Wloga, D., Gay, S., Klonowski, K.D., Wells, L., and Dougan, S.T. (2009) O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. BMC Developmental Biology. 9:28
- Sohn, K.C., and Do, S.I. (2005) Transcriptional regulation and O-GlcNAcylation activity of zebrafish OGT during embryogenesis. Biochemical and Biophysical Research Communications. 337(1):256-263
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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