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ZIRC
ZFIN ID: ZDB-GENE-030131-9544
Gene Name: minichromosome maintenance complex component 4
Gene Symbol: mcm4    Nomenclature History

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Previous Names: cb1025 (1), fc12c09, fj85g09, hm:zeh1616 (1), wu:fc12c09 (1), wu:fj85g09 (1), zeh1616

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits chromatin binding activity. Involved in response to yeast. Predicted to localize to the MCM complex and nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in digestive system; nervous system; otic vesicle; pectoral fin; and proliferative region. Orthologous to human MCM4 (minichromosome maintenance complex component 4).
Genome Resources: Alliance (1),  Gene:337598 (1),  Ensembl(GRCz11):ENSDARG00000040041 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023020Tg Transgenic Insertion Unknown Unknown DNA
sa1949 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12196 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18098 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37936 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mcm4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Immunodeficiency 54 609981
    DISEASE ASSOCIATED WITH mcm4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to yeast (more)
    Cellular Component MCM complex (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 19)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mcm4 polyclonal Rabbit WB Bethyl Laboratories, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mcm4 No data available
    MARKER RELATIONSHIPS
    mcm4 Contains: [SNP] rs3729347 (1)
    mcm4 Encodes: [EST] cb1025 (1) (order this), fb17a01 (1) (order this), fc12c09, fj85g09, zeh1616
    [cDNA] MGC:65771 (1) (order this), MGC:77330 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_198913 (1)
    Genomic GenBank:CABZ01035656 (1) 25186 bp
    Select Tool
    Polypeptide UniProtKB:Q6NZV2 (1) 845 aa
    Sequence Clusters UniGene:76603 (1)
    Sequence Information (all 26)
    ORTHOLOGY for mcm4 ( Chr: 24 )
    CITATIONS (41)