Gene
mcm4
- ID
- ZDB-GENE-030131-9544
- Name
- minichromosome maintenance complex component 4
- Symbol
- mcm4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables chromatin binding activity. Acts upstream of or within response to yeast. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in digestive system; nervous system; otic vesicle; pectoral fin; and proliferative region. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1025 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 54 | Alliance | Immunodeficiency 54 | 609981 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018525 | Mini-chromosome maintenance, conserved site |
| Domain | IPR001208 | MCM domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR027925 | MCM, N-terminal domain |
| Domain | IPR033762 | MCM OB domain |
| Domain | IPR041562 | MCM, AAA-lid domain |
| Family | IPR008047 | Mini-chromosome maintenance complex protein 4 |
| Family | IPR031327 | Mini-chromosome maintenance protein |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | MCM, AAA-lid domain | MCM domain | MCM, N-terminal domain | MCM OB domain | Mini-chromosome maintenance complex protein 4 | Mini-chromosome maintenance, conserved site | Mini-chromosome maintenance protein | Nucleic acid-binding, OB-fold | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NZV2
|
845 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-mcm4 | polyclonal | Rabbit |
|
Bethyl Laboratories, Inc.
|
2 |
Plasmids
No data available