Gene
sparc
- ID
- ZDB-GENE-030131-9
- Name
- secreted protein, acidic, cysteine-rich (osteonectin)
- Symbol
- sparc Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including erythrocyte differentiation; inner ear morphogenesis; and pharyngeal system development. Predicted to localize to extracellular space. Is expressed in several structures, including cranium; hematopoietic system; pectoral fin; pectoral fin bud; and vestibuloauditory system. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 35 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6910025 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
osteogenesis imperfecta type 17 | Alliance | Osteogenesis imperfecta, type XVII | 616507 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
Conserved_site | IPR001999 | Osteonectin-like, conserved site |
Domain | IPR002350 | Kazal domain |
Domain | IPR003645 | Follistatin-like, N-terminal |
Domain | IPR015369 | Follistatin/Osteonectin EGF domain |
Domain | IPR019577 | SPARC/Testican, calcium-binding domain |
Domain | IPR037641 | SPARC, follistatin-like domain |
Homologous_superfamily | IPR011992 | EF-hand domain pair |
Homologous_superfamily | IPR036058 | Kazal domain superfamily |
Domain Details Per Protein
Protein | Length | EF-Hand 1, calcium-binding site | EF-hand domain pair | Follistatin-like, N-terminal | Follistatin/Osteonectin EGF domain | Kazal domain | Kazal domain superfamily | Osteonectin-like, conserved site | SPARC, follistatin-like domain | SPARC/Testican, calcium-binding domain |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6IQH0
|
291 |
Interactions and Pathways
No data available
Plasmids
No data available