Gene
sparc
- ID
- ZDB-GENE-030131-9
- Name
- secreted protein, acidic, cysteine-rich (osteonectin)
- Symbol
- sparc Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Acts upstream of or within several processes, including erythrocyte differentiation; inner ear morphogenesis; and pharyngeal system development. Predicted to be located in basement membrane and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cranium; hematopoietic system; pectoral fin; pectoral fin bud; and vestibuloauditory system. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6910025 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018906Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027518Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa22480 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22481 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| ue112 | Allele with one insertion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sparc | Keatinge et al., 2021 | |
| CRISPR2-sparc | Keatinge et al., 2021 | |
| MO1-sparc | N/A | (2) |
| MO2-sparc | N/A | (2) |
| MO3-sparc | N/A | (2) |
| MO4-sparc | N/A | Kang et al., 2008 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteogenesis imperfecta type 17 | Alliance | Osteogenesis imperfecta, type XVII | 616507 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Conserved_site | IPR001999 | Osteonectin-like, conserved site |
| Domain | IPR002350 | Kazal domain |
| Domain | IPR003645 | Follistatin-like, N-terminal |
| Domain | IPR015369 | Follistatin/Osteonectin EGF domain |
| Domain | IPR019577 | SPARC/Testican, calcium-binding domain |
| Domain | IPR037641 | SPARC, follistatin-like domain |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain pair | Follistatin-like, N-terminal | Follistatin/Osteonectin EGF domain | Kazal domain | Kazal domain superfamily | Osteonectin-like, conserved site | SPARC, follistatin-like domain | SPARC/Testican, calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6IQH0 | InterPro | 291 | |||||||||
| UniProtKB:A0AB32T306 | InterPro | 282 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sparc-201
(1)
|
Ensembl | 1,724 nt | ||
| mRNA |
sparc-202
(1)
|
Ensembl | 865 nt | ||
| mRNA |
sparc-203
(1)
|
Ensembl | 544 nt | ||
| mRNA |
sparc-206
(1)
|
Ensembl | 520 nt | ||
| mRNA |
sparc-207
(1)
|
Ensembl | 2,567 nt | ||
| ncRNA |
sparc-005
(1)
|
Ensembl | 836 nt | ||
| ncRNA |
sparc-006
(1)
|
Ensembl | 726 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-97O1 | ZFIN Curated Data | |
| Contains | SNP | rs3727771 | ||
| Contains | SNP | rs3727772 | ||
| Contains | SNP | rs3727773 | ||
| Contains | SNP | rs3727774 | ||
| Encodes | EST | IMAGE:6910025 | Thisse et al., 2004 | |
| Encodes | EST | zeh0062 | ||
| Encodes | cDNA | MGC:86767 | ZFIN Curated Data | |
| Has Artifact | EST | fa96a08 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001942 (1) | 1688 nt | ||
| Genomic | GenBank:BX640507 (2) | 189019 nt | ||
| Polypeptide | UniProtKB:Q6IQH0 (1) | 291 aa |
- Cotti, S., Di Biagio, C., Huysseune, A., Koppe, W., Forlino, A., Witten, P.E. (2024) Matrix first, minerals later: fine-tuned dietary phosphate increases bone formation in zebrafish. JBMR plus. 8:ziae081ziae081
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Guo, W., Jin, P., Li, R., Huang, L., Liu, Z., Li, H., Zhou, T., Fang, B., Xia, L. (2023) Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis. Experimental & molecular medicine. 55(1):81-94
- Jin, Z., Wang, D., Lv, H., Wu, B., Li, Z., Guo, X., Wang, H., Yang, S. (2023) Loss of the adaptor protein Sh3bgrl initiates ovarian fibrosis in zebrafish. FEBS letters. 597(21):2643-2655
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Bergen, D.J.M., Tong, Q., Shukla, A., Newham, E., Zethof, J., Lundberg, M., Ryan, R., Youlten, S.E., Frysz, M., Croucher, P.I., Flik, G., Richardson, R.J., Kemp, J.P., Hammond, C.L., Metz, J.R. (2022) Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology. 20:21
- Brandão, A.S., Borbinha, J., Pereira, T., Brito, P.H., Lourenço, R., Bensimon-Brito, A., Jacinto, A. (2022) A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration. eLIFE. 11
- Dalle Carbonare, L., Bertacco, J., Gaglio, S.C., Minoia, A., Cominacini, M., Cheri, S., Deiana, M., Marchetto, G., Bisognin, A., Gandini, A., Antoniazzi, F., Perduca, M., Mottes, M., Valenti, M.T. (2022) Fisetin: An Integrated Approach to Identify a Strategy Promoting Osteogenesis. Frontiers in pharmacology. 13:890693
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
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