Gene
med14
- ID
- ZDB-GENE-030131-8867
- Name
- mediator complex subunit 14
- Symbol
- med14 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable transcription coregulator activity. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; regulation of T cell differentiation in thymus; and ventricular system development. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in head and trunk. Orthologous to human MED14 (mediator complex subunit 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Burrows et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2143Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| m628 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| m673 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| s201 | unknown | Unknown | Unknown | ENU | |
| s231 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34688 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 6 of 6
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-med14 | N/A | Burrows et al., 2015 |
| MO2-med14 | N/A | Sertori et al., 2022 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR055107 | Mediator of RNA polymerase II transcription subunit 14, RM8 |
| Domain | IPR055113 | Mediator of RNA polymerase II transcription subunit 14, RM2 |
| Domain | IPR055114 | Mediator of RNA polymerase II transcription subunit 14, RM6 |
| Domain | IPR055122 | Mediator complex subunit MED14, N-terminal |
| Family | IPR013947 | Mediator complex, subunit Med14 |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Mediator complex, subunit Med14 | Mediator complex subunit MED14, N-terminal | Mediator of RNA polymerase II transcription subunit 14, RM2 | Mediator of RNA polymerase II transcription subunit 14, RM6 | Mediator of RNA polymerase II transcription subunit 14, RM8 |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PFL7 | InterPro | 1422 | |||||
| UniProtKB:F1R9C9 | InterPro | 1421 | |||||
| UniProtKB:E9QDB5 | InterPro | 1379 |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218D20 | ZFIN Curated Data | |
| Encodes | EST | fd21c05 | ||
| Encodes | EST | fk28h11 | ||
| Encodes | EST | IMAGE:7154330 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:56130 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191592 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212765 (1) | 5088 nt | ||
| Genomic | GenBank:BX294189 (1) | 194025 nt | ||
| Polypeptide | UniProtKB:A0A8M1PFL7 (1) | 1422 aa |
- Sertori, R., Lin, J.X., Martinez, E., Rana, S., Sharo, A., Kazemian, M., Sunderam, U., Andrake, M., Shinton, S., Truong, B., Dunbrack, R.M., Liu, C., Srinivasan, R., Brenner, S.E., Seroogy, C.M., Puck, J.M., Leonard, W.J., Wiest, D.L. (2022) Investigation of the causal etiology in a patient with T-B+NK+ immunodeficiency. Frontiers in immunology. 13:928252
- Burrows, J.T., Pearson, B.J., Scott, I.C. (2015) An In Vivo Requirement for the Mediator Subunit Med14 in the Maintenance of Stem Cell Populations. Stem Cell Reports. 4(4):670-84
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lou, X., Burrows, J.T., Scott, I.C. (2015) Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest. BMC Developmental Biology. 15:41
- Lowery, L.A., De Rienzo, G., Gutzman, J.H., and Sive, H. (2009) Characterization and Classification of Zebrafish Brain Morphology Mutants. The Anatomical record. 292(1):94-106
- Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y. (2007) A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Developmental Biology. 307(1):29-42
- Durr, K., Holzschuh, J., Filippi, A., Ettl, A.K., Ryu, S., Shepherd, I.T., and Driever, W. (2006) Differential Roles of Transcriptional Mediator Complex Subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 During Zebrafish Retinal Development. Genetics. 174(2):693-705
- Beis, D., Bartman, T., Jin, S.W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.N., Stainier, D.Y., and Jungblut, B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (Cambridge, England). 132(18):4193-4204
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
1 - 10 of 14
Show