ZFIN is now using GRCz12tu for Genomic Data
Gene
cdc42
- ID
- ZDB-GENE-030131-8783
- Name
- cell division cycle 42
- Symbol
- cdc42 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in cell surface receptor signaling pathway; positive regulation of cell migration involved in sprouting angiogenesis; and positive regulation of filopodium assembly. Acts upstream of or within several processes, including camera-type eye development; melanosome transport; and plasma membrane bounded cell projection assembly. Predicted to be located in cytoplasm and midbody. Predicted to be active in plasma membrane. Is expressed in blastodisc; brain; eye; primordial germ cell; and pronephros. Human ortholog(s) of this gene implicated in fibrosarcoma and intellectual disability. Orthologous to human CDC42 (cell division cycle 42).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Takenouchi-Kosaki syndrome | 616737 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cdc42 | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q52WY2 | InterPro | 191 | |||||
| UniProtKB:Q6PFU4 | InterPro | 191 |
- Genome Browsers
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cdc42 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
3 |
Plasmids
- Genome Browsers