Gene

cdc42

ID
ZDB-GENE-030131-8783
Name
cell division cycle 42
Symbol
cdc42 Nomenclature History
Previous Names
  • cdc42a (1)
  • fj62g06
  • wu:fb07d08
  • wu:fj62g06 (1)
  • zgc:63918
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including camera-type eye development; cell surface receptor signaling pathway; and plasma membrane bounded cell projection assembly. Predicted to localize to several cellular components, including cell cortex; cytoplasmic vesicle; and dendritic spine. Is expressed in blastodisc; brain; eye; and pronephros. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdc42 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Takenouchi-Kosaki syndrome 616737
Associated With cdc42 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Family IPR001806 Small GTPase
Family IPR003578 Small GTPase Rho
Family IPR037874 Cdc42
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Cdc42 P-loop containing nucleoside triphosphate hydrolase Small GTPase Small GTPase Rho Small GTP-binding protein domain
UniProtKB:Q6PFU4 191
UniProtKB:Q52WY2 191
UniProtKB:Q6TH34 190
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cdc42 polyclonal IgG Rabbit
  • IHC
Santa Cruz Biotechnology, Inc.
3
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations