Gene
sod3b
- ID
- ZDB-GENE-030131-8743
- Name
- superoxide dismutase 3, extracellular b
- Symbol
- sod3b Nomenclature History
- Previous Names
-
- sod3
- fb05f10
- si:dkey-117m1.6
- wu:fb05f10 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables heparin binding activity and superoxide dismutase activity. Predicted to be involved in removal of superoxide radicals. Predicted to act upstream of or within superoxide metabolic process. Is expressed in several structures, including eye; head mesenchyme; hyaloid vessel; male organism; and skeletal system. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Superoxide dismutase, elevated extracellular] |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018152 | Superoxide dismutase, copper/zinc, binding site |
| Domain | IPR001424 | Superoxide dismutase, copper/zinc binding domain |
| Family | IPR024134 | Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone |
| Homologous_superfamily | IPR036423 | Superoxide dismutase-like, copper/zinc binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Superoxide dismutase, copper/zinc binding domain | Superoxide dismutase, copper/zinc, binding site | Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone | Superoxide dismutase-like, copper/zinc binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:E9QIM2 | InterPro | 192 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-261D5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-117M1 | ZFIN Curated Data | |
| Encodes | EST | fb05f10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068221510 (1) | 1584 nt | ||
| Genomic | GenBank:CR847546 (1) | 144986 nt | ||
| Polypeptide | UniProtKB:E9QIM2 (1) | 192 aa |
- Qin, M.C., Li, J.J., Zheng, Y.T., Li, Y.J., Zhang, Y.X., Ou, R.X., He, W.Y., Zhao, J.M., Liu, S.T., Liu, M.H., Lin, H.Y., Gao, L. (2023) Naringin ameliorates liver fibrosis in zebrafish by modulating IDO1-mediated lipid metabolism and inflammatory infiltration. Food & function. 14(23):10347-10361
- Xu, H., Mao, X., Nie, Z., Li, Y. (2023) Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Free radical biology & medicine. 203:102-113
- Matthiesen, C.L., Hu, L., Torslev, A.S., Poulsen, E.T., Larsen, U.G., Kjaer-Sorensen, K., Thomsen, J.S., Brüel, A., Enghild, J.J., Oxvig, C., Petersen, S.V. (2021) Superoxide dismutase 3 is expressed in bone tissue and required for normal bone homeostasis and mineralization. Free radical biology & medicine. 164:399-409
- Xu, H., Wang, G., Chi, Y.Y., Kou, Y.X., Li, Y. (2021) Expression profiling and functional characterization of the duplicated Oxr1b gene in zebrafish. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 39:100857
- Sendra, M., Pereiro, P., Yeste, M.P., Mercado, L., Figueras, A., Novoa, B. (2020) Size matters: Zebrafish (Danio rerio) as a model to study toxicity of nanoplastics from cells to the whole organism. Environmental pollution (Barking, Essex : 1987). 268:115769
- Xu, H., Jiang, Y., Li, S., Xie, L., Tao, Y.X., Li, Y. (2020) Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging. Genes. 11(10):
- Zhang, X., Zhou, Q., Li, X., Zou, W., Hu, X. (2020) Integrating omics and traditional analyses to profile the synergistic toxicity of graphene oxide and triphenyl phosphate. Environmental pollution (Barking, Essex : 1987). 263:114473
- Bereketoglu, C., Pradhan, A. (2019) Comparative transcriptional analysis of methylparaben and propylparaben in zebrafish. The Science of the total environment. 671:129-139
- Mathiyalagan, N., Miles, L.B., Anderson, P.J., Wilanowski, T., Grills, B.L., McDonald, S.J., Keightley, M.C., Charzynska, A., Dabrowski, M., Dworkin, S. (2019) Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Genes. 10(11)
- Novoa, B., Pereiro, P., López-Muñoz, A., Varela, M., Forn-Cuní, G., Anchelin, M., Dios, S., Romero, A., Martinez-López, A., Medina-Gali, R.M., Collado, M., Coll, J., Estepa, A., Cayuela, M.L., Mulero, V., Figueras, A. (2019) Rag1 immunodeficiency-induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress. Aging Cell. 18(5):e13020
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