Gene

tubb4b

ID
ZDB-GENE-030131-8625
Name
tubulin, beta 4B class IVb
Symbol
tubb4b Nomenclature History
Previous Names
  • tubb2 (1)
  • tubb2c
  • fa91f09
  • fb16e09
  • wu:fa91f09 (1)
  • wu:fa92d05
  • wu:fb16e09
  • wu:fb97a11
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in cilium assembly. Predicted to localize to cytoplasm and microtubule. Is expressed in brain. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Orthologous to several human genes including TUBB4B (tubulin beta 4B class IVb).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Shim et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tubb4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leber congenital amaurosis with early-onset deafness Alliance Leber congenital amaurosis with early-onset deafness 617879
Associated With tubb4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR013838 Beta tubulin, autoregulation binding site
Conserved_site IPR017975 Tubulin, conserved site
Domain IPR003008 Tubulin/FtsZ, GTPase domain
Domain IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
Family IPR000217 Tubulin
Family IPR002453 Beta tubulin
Homologous_superfamily IPR008280 Tubulin/FtsZ, C-terminal
Homologous_superfamily IPR023123 Tubulin, C-terminal
Homologous_superfamily IPR036525 Tubulin/FtsZ, GTPase domain superfamily
Homologous_superfamily IPR037103 Tubulin/FtsZ, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Beta tubulin Beta tubulin, autoregulation binding site Tubulin Tubulin, conserved site Tubulin, C-terminal Tubulin/FtsZ, 2-layer sandwich domain Tubulin/FtsZ, C-terminal Tubulin/FtsZ, C-terminal domain superfamily Tubulin/FtsZ, GTPase domain Tubulin/FtsZ, GTPase domain superfamily
UniProtKB:Q6TGT0 445
UniProtKB:Q9IAB4 60
UniProtKB:A0A0R4IXL7 114
UniProtKB:Q6P5M9 445
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations