Gene
atg3
- ID
- ZDB-GENE-030131-8576
- Name
- autophagy related 3
- Symbol
- atg3 Nomenclature History
- Previous Names
-
- apg3
- apg3l
- im:6910145
- wu:fb15g12
- zgc:64156 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable Atg12 transferase activity; Atg8-family conjugating enzyme activity; and Atg8-family ligase activity. Predicted to be involved in autophagy of mitochondrion; macroautophagy; and mitochondrial fragmentation involved in apoptotic process. Predicted to act upstream of or within autophagy and protein transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol and phagophore assembly site. Is expressed in several structures, including heart; liver; male organism; muscle; and yolk syncytial layer. Orthologous to human ATG3 (autophagy related 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64156 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015987Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-atg3 | Chen et al., 2023 | |
| MO1-atg3 | N/A | Chen et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR007135 | Ubiquitin-like-conjugating enzyme Atg3/Atg10 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ubiquitin-like-conjugating enzyme Atg3/Atg10 |
|---|---|---|---|
| UniProtKB:Q6PFS7 | InterPro | 317 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-atg3 | polyclonal | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-237C6 | ZFIN Curated Data | |
| Encodes | EST | fb15g12 | ||
| Encodes | EST | IMAGE:6910145 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:64156 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200022 (1) | 1666 nt | ||
| Genomic | GenBank:CU655960 (1) | 123312 nt | ||
| Polypeptide | UniProtKB:Q6PFS7 (1) | 317 aa |
- Chen, X.K., Yi, Z.N., Lau, J.J., Ma, A.C. (2023) Distinct roles of core autophagy-related genes in zebrafish definitive hematopoiesis. Autophagy. 20(4):830-846
- Xu, F.H., Qiu, Y.Z., Zhang, Y., Yang, F.H., Ji, M.M., Liu, K.C., Jin, M., Zhang, S.S., Li, B. (2023) The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish. Food & function. 14(13):6157-6171
- Singh, M.K., Yadav, R., Bhaskar, A.K., Sengupta, S., Sachidanandan, C. (2022) A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(1):159246
- Li, Z., Li, B., Wang, J., Lu, Y., Chen, A.F.Y., Sun, K., Yu, Y., Chen, S. (2021) GAA deficiency promotes angiogenesis through upregulation of Rac1 induced by autophagy disorder. Biochimica et biophysica acta. Molecular cell research. 1868(5):118969
- Singh, M.K., Jayarajan, R., Varshney, S., Upadrasta, S., Singh, A., Yadav, R., Scaria, V., Sengupta, S., Shanmugam, D., Shalimar, ., Sivasubbu, S., Gandotra, S., Sachidanandan, C. (2021) Chronic systemic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(5):158905
- Wu, Z., Wang, F., Hu, L., Zhang, J., Chen, D., Zhao, S. (2021) Inhibition of endoplasmic reticulum stress-related autophagy attenuates MCLR-induced apoptosis in zebrafish testis and mouse TM4 cells. Ecotoxicology and environmental safety. 221:112438
- Enomoto, H., Mittal, N., Inomata, T., Arimura, T., Izumi, T., Kimura, A., Fukuda, K., Makino, S. (2020) Dilated Cardiomyopathy (DCM)-linked Heat shock protein Family D Member 1 (HSPD1) mutations cause upregulation of ROS and autophagy through mitochondrial dysfunction. Cardiovascular research. 117(4):1118-1131
- Qin, J., Ru, S., Wang, W., Hao, L., Ru, Y., Wang, J., Zhang, X. (2020) Long-term bisphenol S exposure aggravates non-alcoholic fatty liver by regulating lipid metabolism and inducing endoplasmic reticulum stress response with activation of unfolded protein response in male zebrafish. Environmental pollution (Barking, Essex : 1987). 263:114535
- Yatsuka, H., Hada, K., Shiraishi, H., Umeda, R., Morisaki, I., Urushibata, H., Shimizu, N., Sebastian, W.A., Hikida, T., Ishitani, T., Hanada, R., Shimada, T., Kimoto, K., Kubota, T., Hanada, T. (2020) Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish. Biochemical and Biophysical Research Communications. 533:1470-1476
- Hu, Z., Chen, B., Zhao, Q. (2019) Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy. Biology Open. 8(5):
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