Gene

optn

ID
ZDB-GENE-030131-8103
Name
optineurin
Symbol
optn Nomenclature History
Previous Names
  • si:ch211-240l19.3
  • wu:fj52f04
  • zgc:66386
  • zgc:77868
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have K63-linked polyubiquitin modification-dependent protein binding activity. Involved in axonogenesis and vesicle localization. Predicted to localize to Golgi apparatus and nucleus. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Is expressed in several structures, including eye; otic vesicle; periocular mesenchyme; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human OPTN (optineurin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With optn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Amyotrophic lateral sclerosis 12 with or without frontotemporal dementia 613435
Glaucoma 1, open angle, E 137760
{Glaucoma, normal tension, susceptibility to} 606657
Associated With optn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR021063 NF-kappa-B essential modulator NEMO, N-terminal
Domain IPR032419 NF-kappa-B essential modulator NEMO, CC2-LZ domain
Domain IPR034735 NEMO, Zinc finger
Domain Details Per Protein
Protein Length NEMO, Zinc finger NF-kappa-B essential modulator NEMO, CC2-LZ domain NF-kappa-B essential modulator NEMO, N-terminal
UniProtKB:A0A8M9Q5S4 519
UniProtKB:Q5RI56 517
UniProtKB:A0A8M9QAZ9 522
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-optn polyclonal Rabbit
  • WB
Cayman Chemical Company
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations